Ergot Alkaloid

Question 1

Therapeutic Class

Answer 1

labor inducer (uterine contractions)

Question 2

Examples

Answer 2

methylergonovine (Methergine)

Question 3

Mechanism of Action

Answer 3

acts on smooth muscle of uterus which increases tone, rate and amplitude of contractions ions

Question 4

Actions and Uses

Answer 4

for uterine atony unresponsive to massage

-prevention and control of post-partum hemorrhage

Question 5

Adverse Effects

Answer 5

shock, severe hypertension, dysrhythmias

Question 6

Black Box Warning

Answer 6

can cause uterine rupture

Question 7

contraindications

Answer 7

headache
migrane
stroke
eclampsia
heart disease
Raynaud's phenomenon
cholestasis
renal disease
pulmonarydisease

Question 8

Interactions (over 50 drug interactions)

Answer 8

• CYP 3A4 inhibitors decrease methylergonovine: macrolide antibiotics (erythromycin, clarithromycin) HIV protease / reverse transcriptase inhibitors (ritonavir, indinavir, nelfinavir, delavirdine) & azole antifungals (ketoconazole, itraconazole, voriconazole, fluconazole, clotrimazole), fluoxetine,
• Food: Grapefruit juice

Question 9

Preg Cat

Answer 9

C, however only indicated after delivery