Erythrocyte Physiology Flashcards Preview

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Flashcards in Erythrocyte Physiology Deck (11)
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1

Hematocrit

Height of RBCs / total height (in centrifuged blood sample)

2

Functions of blood (4)

Deliver nutrients and oxygen
remove waste products
maintain homeostasis
circulate hormones, immunoglobulins

3

Composition of blood (2)

Plasma - solution component of blood: electrolytes, proteins, carbohydrates, lipids, clotting factors
Formed elements - erythrocytes, leukocytes, platelets

4

Functions of erythrocytes (3)

Carry O2 from lungs to body
Carry CO2 from body to lungs
Acid/Base buffering

5

HIF

Hypoxia inducible factor - transcription factor that upregulates production of erythropoietin in hypoxic conditions

6

EPO stimulated by

HIF (TF)
Anemia
Low renal blood flow
Central hypoxia (high altitude, pulmonary disease)

7

Regulation of Erythrocytes

Tissue oxygenation decreases EPO secretion, decreasing amount of RBCs produced
Important because too many RBCs will impede blood flow

8

Hypochromic anemia

deficient transport of transferrin

9

Oxygen capacity

maximum amount of oxygen that can be carried by hemoglobin in blood (all four hemes bound O2)

10

Oxygen Saturation

how much oxygen is actually being carried by the blood ( 19.5 mL O2/dL)

11

Oxygen content

Maximum capacity x saturation: Spots occupied by oxygen as a percentage of total available spots