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Flashcards in erythrocytic disorders Deck (93):
1

erythrocytic disorders may be due to

alterations in number
abnormality in morphology

2

reduction in the concentration og hgb or hct level in the peripheral blood below normal

anemia

3

causes of anemia

impaired red cell prod
blood loss
inc. rbs destruction (destruction > production)

4

anemia panel

cbc with indices
retic
osmotic frag
sucrose hemo
ham's
iron
tibc
ferritin
b12
folate
electrophoresis

5

expected cbc results in anemia

dec. hct hgc rbc count

6

expected cbc indices in anemia

de. mcv mch mchc

7

average volume of individual rbc, classification into micro macro normocytic

MCV

8

mcv formula

hct/rbc x 10

9

mcv for normocytic cells

82-92 fL

10

microcytic cells seen in

IDA
secondary anemia

11

macrocytic cells see in

b12 def
folate def

12

pathologic variation in cell size

anisocytosis

13

amount of hgb by weight in an average rbc, classification into hypo hyper normochromic

MCH

14

mch formula

hgb/rbc x 10

15

NV for mch

27-31 ug

16

concentration of hgb in an average rbc

mchc

17

mchc formula

hgb/hct x 100

18

NV for mchc

33-38%

19

conditions associated with changes in hgb content

hypo hyper aniso polychromasia

20

dec in hgb cocn thus giving a central pallor to the red cell s exceeding half of the diameter

hypochromasia

21

hypochromasia seen in

IDA
thalassemia

22

stains unequally with only a proportion of the cells appearing hypochromic

anisochromasia

23

anisochromasia seen in

after transfusion in IDA patients

24

unusual deep staining of the rbc, no central pallor

hyperchromasia

25

rbc takes a slightly basophilic hue having a bluegray coloration with the presence of rNA

polytchromasia

26

presence of rna in rbc indicates

rbc delivered prematurely into circu

27

polychromasia seen in

inc erythropoietic activity
hemorrhage
hemolysis

28

variation in shape of rbc

poikilocytosis

29

inc. pilikilocytosis is indicative of

abnormal erythropoiesis

30

inc. poikilocytosis may be due to

bone marrow deficit
abnormal rbc destruction

31

spherocytes are seen in

HS
immune induced hemolysis
post transfusion

32

defect in shape in spherocytes are due to

low surface area to volume ratio
loss of membrane function

33

regular small tipped p[rojection all around the cell

echinocyte

34

defects of echinocytes are in

depletion of atp
exposure to hypertonic sol
artifact in airdrying

35

echinocytes seen in

very anemic
uremia
cirrhosis
hepatitis
chrinic renal failure

36

spheroid with irregular spike spicules

acanthocyte

37

cause of acnthocyte

increased chole to lecithin ratio

38

acanthocytes seen in

congenital or acquired abetalipoproteinemia
hemolytic anemia
end stage liver dse
pyruvate kinase def

39

red cell fragments

schistocytes

40

defects in schistocyte may be due to

fibrin
prosthetic valves
alterd blood vessel walls

41

schistocyets seen in

DIC
TTP
burns
microangiopathoc hemolytic anemia

42

egglike or oval shaped wider than elliptocytes

ovalocytes

43

defect in ovalocytes

dec chole
hgb has bipolar arrangement

44

ovalocytes seen in

megaloblastic bone marrow
myelodysplasia
sickle cell anemia

45

abnormally thin cell resembling a target

target cell/codocyte

46

target cells seen in

thalssemia major
obstructive jaundice
hb SC dse
LCAT

47

rbc with central stroma or mouth which appear as am unstained central biconcave area

stomatocytes

48

defects in stomatocytes due to

slow drying artifact
increased permeability to sodium

49

stomatocytes seen in

h. stomatocytosis
acute alcoholism
liver dse

50

crescent shaped cell that lacks zone of central pallor

sickle cell/drepanocyte

51

defect in sickle cell is due to

plymerization of deoxygenatiod hgb

52

drepanocytes seen in

sickle cell anemia
sickle thalassemia
sickle cell dse

53

teardrop shaped with single elongated point

dacryocyte

54

defect in dacryocyte is due to

squeezing and fragmentation during spleenic passage

55

dacryocyte seen in

myeloid metaplasia
thalassemia
megaloblastic
hypersplenism

56

rod or cigar shaped

elliptocytes

57

defect in elliptocytes due to

polarization of hgb

58

elliptocytes seen is

HE
thalassemia
IDA

59

fine or coarse gray-black granules in rbcs

basophilic stipplings

60

basophilic stipplings seen in

lead poisoning
thalassemia
heavy metals
inc retics

61

coarse round densely stained granules eccentrically

howell-joll ly bodies

62

remnants of nuclear chromatin within the rbc containing dna

howell jolly

63

red violet structures appearing as ring, incomplete figure of 8

cabot ring

64

howell jolly bosies seen in

megalo
severe homylsis
thalass
accel erythropoi

65

remnants of microtubules of mitotic spindle

cabot eings

66

cabot rings seen in

severe anemia

67

nonnucleated rbc containing bright blue nonhgb iron granules

siderocyres

68

defect in siderocytes are due to

excessive iron overloading in mitochondria of normoblast
defective hene synth

69

siderocytes seen in

hemolytic anemia
after splenectomy

70

retic formula

retic counted/1000 rbc x 100

71

NV retic

.5-1.5%

72

rgt in osmotic frag test

hypotonic sol

73

used to diagnsoe PNH hypoplastic anemia megaloblastic anemia

sucrose hemolysis

74

for definitive diagnosis of PNH

ham's acidified serum test

75

PNH cells are unusually susceptible ti

complement

76

spx for iron studies

morning spx red top tube

77

NV for iron

.5-17 ug/dl

78

decreased iron values seen in

mens
preg
infalmmm
MI
malig
IDA

79

Inc iron val seen in

hepa
oral contra
inc ingestion

80

only vitain exclusively synthesized y microorganism

vit12 cobalamine

81

NV for cobalamine

200-900 ng/L (pg/ml)

82

cobalamine deficiency is caused by

inadequate intake
gastrectomy (no intrinsic factor)
pernicios anemia
defective absorption

83

diagnostic procedures for cobalamine

serum b12 assay
therapeutic trial
urinary methyl maloric assay
deoxyuridine suppresion test

84

iron is deposited in tissues as iron oxide granules called

hemosiderin

85

ferritin NV adult

12-300 ug/L

86

ferritin NV infant

1-142 ug/L

87

folic acid NV

5-21 ng/mL

88

cobalamine deficiency can also be seen in folate def except in

leukopenia
thrombocytopenia

89

needed for folate def diagnosis thru lab methods

serum folic acid
serum folate
red cell folate

90

urine testing for hemolytic dse

urobil
urobilin
urine hgb

91

special testing for hemolytic anemia

plasma hgb
bilirubin fractionation
DAT

92

tests if congenital anemia is suspected

osmo frag
autohgemoylsis
g6pd
gluta stability
hgb electrophoresis and hgbF
heinz body stain

93

intended for electrophoresis separation of human hgb to screenfor clinically imporatnt variants

paragon hgb electrophoresis