Erythropoiesis & Growth Factors Flashcards Preview

Basic Haemotology (1204) > Erythropoiesis & Growth Factors > Flashcards

Flashcards in Erythropoiesis & Growth Factors Deck (45):
1

Hormone invloved in the stimulation of eythropoiesis

Erythropoetein

2

The name of the committed stem cell involved in the process of Erythropoiesis

Pronormoblast/ Proerythroblast

3

Outline the maturation sequence for erythrocytes.

Hemocytoblast (Stem Cells), Proerythroblasts, Erythroblasts, Normoblasts, Reticulocyte, Erythrocytes

Pronormoblast (Erythroblast), Basophillic Normoblasts (Prorubricyte), Polychromatic Erythroblasts (Rubricyte), Orthochromic Normoblasts (Metarubricyte), Reticulocyte (Polychromatophillic), Mature Erythrocytes

4

The name given to the movement of erythrocytes from the bone marrow and into the blood stream.

Diapedesis

5

Name of the stem cell involved in the process of erythropoiesis.

Hemocytoblast

6

Average life span of red blood cells

120 days

7

How long on average do red blood cells take to fully mature?

4-8 days

8

True or false, the process of Erythropoiesis is irreversible.

True

9

The site of Blood cell Production in 0-2 months prenatally

Yolk sac

10

The site of Blood Cell Production in 2-7 months prenatally

Liver, Spleen

11

The site of Blood Cell Production in 7-9 months prenatally

Bone Marrow

12

The site of Blood cell Production in childhood

Bone marrow of most or all bones

13

The site of Blood Cell Production in Adulthood 20>.

Bone Marrow of Flat Bones. (Illiac crest, skull, sternum etc)

14

What macromolecule deposition causes a decrease in erythropoiesis as age progresses?

Fat

15

The term used to describe when more RBC's are produced than destroyed.

Polycythemia

16

What mechanism does erythropoeitin operate with

Negative Feedback Mechanism

17

What term is given to a decrease of oxygen in the blood which can trigger an increase in erythropoiesis

Hypoxia

18

What cell type can be used to find the erythropoietic activity in the blood

Reticulocyte

19

What is the name of the single class of primitive mother cell

Pluripotent Stem Cells

20

Pluripotent Stem Cells give rise to which two series of blood cells

Myeloid and Lymphoid series

21

What 5 characteristics develops during erythropoiesis

Haemoglobin Accumulation
Nuclear Condensation
Decreased Cell Size
Decreased mRNA
Morphologically Identifiable

22

How many RBCs are made per day

3.5 x 10^11 Cells per day

23

How many Neutrophils are made per day

10^11

24

How many Monocytes are made per day

8.4 x 10^9

25

How many Platelets are made per day

10^11

26

What is the normal Hematocrit percentage in males and females

47, 42 respectively

27

What is the normal red blood cell count in males and females

5.4,4.8

28

What is the normal Haemoglobin Level in males and females

16 and 14 respectively

29

Which organ is the O2 sensor located

Kidney

30

What organ produces Erythropoietin

Kidney

31

What part of the kidney releases erythropoietin

Pertibular interstitial Cells in other cortex

32

What classifies as a an increased erythropoietic activity seen as Reticulocyte percentage

Reticulocyte greater than 2.5%

33

Epic can increase blood viscosity which is a major contributor to which disease

Heart Disease

34

Erythropoietin is used to treat what disease

Anaemia in relation to chronic renal failures, AIDS or cancer chemotherapy

35

Epo can also lead to sudden death due to what 2 factors

Drastic Reduction in Heart Rate
Development of Epo Antibodies which can destroy RBCs

36

What factors decreases oxygenation

Low Blood Volume
Anaemia
Low Haemoglobin
Poor Blood Flow
Pulmonary Disease

37

What is the term given to the heterogeneous group of cytokines that stimulate the progenitor Cells and induce proliferation and maturation

Haemotopoietic Growth Factors

38

True or False, HGF’s Are naturally occurring hormones

True

39

True or False, HGF have a high molecular weight of glycoproteins

False, it is low

40

True or False, HGFs have varying degrees of specificity

True

41

True or False, RGFs are available in purified forms by DNA technology

True

42

True or False, RGFs are responsible for stimulation and release of other growth factors and cytokines

True

43

True or False, production equals destruction in erythropoiesis

True

44

What growth factors causes the growth and proliferation of pluripotent Stem Cells into commited or progenitor Cells

IL-1, IL-6, IL-3

45

What growth factor causes the production of RBCs and platelets from committed Stem Cells

GM-CSF