Essential Pharmacology Flashcards Preview

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Flashcards in Essential Pharmacology Deck (16):
1

Give 2 examples of chemicals that are lipid soluble and can therefore reach intracellular receptors.

-steroid hormones
-NO

2

What does NO do?

-binds to soluble guanylyl cyclase
-generates cGMP as a second messenger which regulates cell activity

3

What are ionotropic receptors?

those where the receptor is also an ion channel

4

An example of a chemical activated by a G-proten coupled receptor is adenylyl cyclase. What does it produce?

cAMP

5

What does cAMP do?

regulates the activity of another enzyme, PKA which is a kinase enzyme

6

What does the G-protein coupled receptor that involves Phospholipase C do?

produces DAG that regulates PKC (a kinase) and IP3 that regulates Ca2+

7

Why are the Gprotein coupled receptors that involve the regulation of PKC and PKA important?

PKA and PKC are kinases that are used to phosphorylate, and therefore regulate, a whole host of cell proteins

8

What is one way of improving the efficacy of a drug?

increasing the amount of drug given (to a certain extent as eventually receptors become saturated)

9

What is the affinity of a drug determined by?

strength of chemical attraction between drug and receptor

10

What is EC50?

half maximal response when half available receptors are activated

11

What does a low EC50 indicate?

a high affinity

12

What is meant by efficacy?

how good the drug is at activating the receptor

13

What do agonist drugs do?

mimic normal effect of receptor

14

What do antagonist drugs do?

block normal action of receptor

15

What type of drug (in action) is salbutamol?

a selective agonist

16

What type of action (in action) is propranolol?

a selective antagonist