etmoidate and precedex Flashcards
(28 cards)
etomidate analgesia
no intrinsic properties
etomidate structure
imidazole ring -open (stable) in solution, closed in body
etomidate PONV?
increases
etomidate special consideration
transient depression of adrenocortical function
transient depression of adrenocortical function puts what kind of people in danger
septic, hemorrhage, people with depressed cortisol function already
etomidate mechanism of action
gaba - potentiation
etomidate CV
CV STABLE!
etomidate duration
extremely short 3-5min
etomidate effect on sz
none. good for ECT
precedex mechanism of action
highly selective a2 adrenergic agonist
how does alpha 2 work
negative feedback loop
precedex CNS
decreases MAC requirement and decreases anesthetic requirement for opiod
precedex resp
safer
precedex has a high potential for
tolerance/ withdrawal
precedex contraindicated after
24h
precedex effect on ventilatory response to CO2
none - doesnt blunt chemoreceptors
the release of glucocorticoids is triggered by
hypothalamus and pituitary
does etomidate release histamine
no
etomidate CNS
decreased CBF, CMRO2, ICP, IOP
etomidate resp
suppress MV and increase RR, dec response to CO2
metabolite of etomidate
inactive
precedex considerations for women and children
cognitive effects - single exposure association w grades and IQ. 3rd trimester, 3 years old
analgesia for precedex originates at
level of spinal cord
what shouldn’t you give someone who’s in withdrawl from precedex
beta blockers . it will block beta but not alpha. severe peripheral vacosonstriction
