EX1 Antigen Processing/Presentation - Stiner Flashcards Preview

SP14 Microbiology > EX1 Antigen Processing/Presentation - Stiner > Flashcards

Flashcards in EX1 Antigen Processing/Presentation - Stiner Deck (39):
1

CD8 cells recognize MHC class (I or II)

MHC class I

2

CD4 cells recognize MHC class (I or II)

MHC class II

3

______ _____ is the bridge between antigen recognition and the ignition of a full-blown immune response

antigen presentation

4

Antigen presentation enables T cell-mediated _______ or augments antibody production by ______

killing
B cells

5

Antigen presentation is ______ ______, allowing the deployments of appropriate immune responses under different conditions

context dependent

6

Antigen recognition without antigen presentation can result in ________, this minimize the chances of _________ activity

tolerance
autoimmune

7

Antigen presentation is modulated by _______ _______

co-stimulatory molecules

8

Successful antigen presentation results in activation of _______

T cells

9

What are the three main antigen presenting cells (APCs)

dendritic cels
macrophages
B cells

10

All nucleated cells can present endogenous antigens in association with MHC class (I or II) molecules

MHC class I

11

Pathway 1 of antigen processing involves (endogenous/exogenous) antigens

exogenous

12

Pathway 2 of antigen processing involves (endogenous/exogenous) antigens

endogenous

13

In this pathway of antigen processing the antigens are digested to small peptides and presented to CD8 cells via MHC class I; uses ubiquitin

Pathway 2 (cytosolic pathway)

14

In this pathway of antigen processing the antigens are taken into the cell, small peptides are generated and presented to CD4 cells via MHC class II

Pathway 1 (endocytic pathway)

15

The processes by which antigens are digested and placed on the cell surface with correct MHC molecules

antigen processing

16

The invariant chain/CLIP of MHC class II processing does what?

keeps the MHC from binding with anything while it is forming/traveling

17

Both class I and class II MHCs are formed in the ______

rough endoplasmic reticulum (RER)

18

MHC class (I or II) makes use of an endocytic compartment containing the antigen to be presented

MHC class II

19

MHC class (I or II) contains α1, α2, α3, and a β2 component

MHC class I

20

MHC class (I or II) contains an α1, α2, β1, and a β2 component

MHC class II

21

MHC haplotypes can influence three things like...

how an individual responds to certain pathogens
susceptibility to certain diseases
transplant success

22

True or False
MHC genes are highly polymorphic

True; roughly 10^13 different combinations; the alleles are co-dominantly expressed

23

True or False
MHC molecules have a broad specificity for peptides

True; many different peptides can bind within MHC binding clefts

24

True or False
Peptides associated with MHC have a rapid on and rapid off rate

False; they have a slow on and off rate

25

True or False
MHC molecules do discriminate from self and foreign peptides

False; they do not discriminate

26

MHC ________ allows individual T cells to recognize foreign antigens displayed on the surface on an individual APC; allowing recognition of self or non-slef

MHC restriction

27

True or False
In order for the antigen to be properly presented the T-cell receptor (TCR) must engage the MHC molecule and other co-stimulatory molecules

True

28

The main secondary signals of MHC/TCR recognition are ______ and _____

CD28 (on T cell)
B7 (on APC)

29

Which T cell recognizes cytosolic proteins

CD8

30

Which T cell recognizes extracellular/intravascular pathogens

CD4

31

____ and ____ are non-covalently associated to the TCR and they are required for antigen recognition and signaling

CD3 and ζ (zeta)

32

_______ competitively binds to B7; blocking signals from the TCR

CTLA-4

33

True or False
You must have both the MHC and co-stimuntory molecule in orderer for the T cell to be activated

True

34

What interleukin drives the development of Th1 cells

IL-12

35

What interleukin drives the development of Th2 cells

IL-4

36

Th (1 or 2) cells provide help for cell mediated immune responses

Th1

37

This is an important Th1 cytokine

IFN-γ

38

Th (1 or 2) cells provide help for humoral immune responses

Th2

39

This is an important Th2 cytokine

IL-4