EX2; Dentin/Pulp Complex 1 Flashcards Preview

May14 Oral Histology > EX2; Dentin/Pulp Complex 1 > Flashcards

Flashcards in EX2; Dentin/Pulp Complex 1 Deck (81):
1

This the soft connective tissue in the tooth center with blood vessels and whole cells

pulp

2

Is the pulp mineralized or non-mineralized

non-mineralized

3

This is the mineralized connective tissue covering the pulp with no blood vessels or whole cells

dentin

4

What two things does dentin contain in the tubules

odontoblastic process
nerve endings

5

What is the main clinical significance of dentin

protective of both enamel and pulp

6

This feature of the DEJ facilitates adhesion

scalloping

7

When does dentinogenesi begin

during the bell stage

8

Just prior to dentinogenesis, what occurse

tissues layers of dental organ present
crown outline present
no odontoblasts or ameloblasts

9

In which part of the tooth germ does dentinogenesis begin

the most coronal portion

10

Where does the inductive signal for odontoblast differentiation come from

the enamel organ

11

What is the main signaling molecule/growth factor controlling odontogenesis

Wnt10a

12

This is a signaling molecule that follows Wnt10a; is induced by this

dentin/odontoblast specific marker; DSPP

13

The odontoblast secretes this first then it is mineralized

organic matrix then its mineralized

14

What is the name of the unmineralized organic matrix of dentin

predentin

15

What are the requirements for mineralization

Ca2+ and phosphate

16

Where does the phosphate come from used for mineralization

from plasma and cleavage of organic containing phosphate transported into dentin through and between odontoblasts

17

What are the two sections of crystal formation

mantle
circumpulpal

18

What is the principal component of the organic matrix of mantle dentin

collagen type 1

19

What are the sizes of the collagen fibrils in mantle dentin

relatively large

20

What is the orientation of the mantle dentin fibrils

at right angles to the basal lamina/future DEJ

21

Near the end of mantle dentin formation, what occurs

one dentin process becomes dominant

22

What is different about the circumpulpal dentin compared to mantle dentin

smaller fibrils
parallel to basal lamina

23

Where does the mineralization come from in circumpulpal dentin

not matrix vesicles, it comes from proteins

24

What is circumpulpal dentin synthesized from

synthesized and secreted from odontoblastic process (along with ions)

25

Special properties of the proteins involved in circumpulpal dentin formation

they precipitate Ca2+ ions preset in the interstitial fluid, initiate crystal formation

26

Which dentin is more organic

mantle dentin

27

Which dentin is more mineralized

circumpulpal dentin

28

The DEJ is more vulnerable to what

caries

29

How specific is phosphophoryn/dentin phosphoprotein

relatively specific to dentin

30

What is the prominent dentinal protein

>50% non-collagenous proteins (NCPs)

31

What constitutes to the negative charge of phosphophoryn/dentin phosphoprotein

highly phosphyorlated
high in serine/aspartic acid
acidic/anionic

32

What is the percentage of organic, inorganic, and water of dentin by WEIGHT

inorganc = 70% (HA)
organic = 20%
water = 10%

33

What is the percentage of organic, inorganic, and water of dentin by VOLUME

inorganic = 45%
organic = 33%
water = 22%

34

What is the only physical property that dentin is greater than enamel at

compressive strength

35

What is orientation of the hydroxyapatite crystals

random orientation

36

What makes up the extracellular matrix of the organic phase of dentin

collagen
non-collagenous proteins

37

What are the non-tissue specific proteins that make up the organic phase of dentin

proteoglycans
signaling molecules/growth factors; bone morphogenetic protein

38

What are the mineralized-tissue specific proteins that make up the organic phase of dentin

osteoclastin
bone sialprotein

39

What are the dentin dominant proteins that make up the organic phase of dentin

dentin matrix protein 1
dentin glycoprotein
dentin sialoprotein

40

What type of long chain does dentin phosphoprotein contain

polar amino acid repeats
greater than 200 serine-serine-aspartic acid
phosphorylated serines

41

What would occur is DSPP is mutated (abnormal)

it cannot be released from the odontoblast; stick in the rER or cell membrane

42

What are the changes at the genetic level from a D1 mutation in DSPP

changes in the first three amino acids; iso, pro, val

43

Is the D1 DSPP mutation dominant or recessive inheritance

dominant

44

What is the result in the coding region of DSPP under a D1 mutation

small base pair deletions that produce frame shifts changing the polar amino acid repeats to uncharged

45

mutates DSPP also affects the normal protein made by the cell how

by trapping it

46

What type of mutation is D1 DSPP

dominant negative

47

What is the result if a cell begins to have more DSPP mutatnts

less DSPP is secreted

48

What are the contents of the dentinal tubules

fluid; major component = water
nerve fibers
odontoblastic processes
less collagen fibers
non-cellular lining sheath although organic composition is unknown

49

How are the dentinal tubules in relation to the DEJ

at right angles

50

What is the shape of the dentinal tubules

S-shaped at the crown
straighter in the root

51

What type of branching pattern does the dentinal tubules have

terminal and lateral branches

52

Does inner or outer dentin contain more tubules

inner dentin

53

What is the pattern of depth in the dentin

the number continues to decrease in outer dentin
deep > middle > outer

54

Does inner or outer dentin contain larger tubules

the diameter of tubules is larger in inner dentin

55

Where do the tubules occupy less surface area, at the DEJ or the P-D border

DEJ

56

What increases toward the P-D border

permeability and wetness

57

This dentin formed until the completion of root development

primary dentin

58

True or False
primary dentin does not comprise most of the dentin

False; it does

59

What are the two types of primary dentin

mantle
circumpulpal

60

Which is more mineralized, mantle or circumpulpal dentin

circumpulpal

61

This dentin forms after root development and is formed at a slower rate but throughout life

secondary dentin

62

Where is secondary dentin in relation to primary dentin

central

63

What are the similarities between primary and secondary dentin

similar in structure
also classified as circumpulpal dentin

64

This dentin is produced in specific locations in response to noxious stimulus

tertiary dentin

65

What is the structure of tertiary dentin

structurally irregular
may or may not have tubules
may include cells

66

Where is both intertubular and intratubular dentin found

in primary and secondary dentin

67

Where is intertubular and intratubular dentin found in relation to the tubules

inter = between
intra = lining

68

Does intertubular or intratubular have a greater volume

inter

69

Does intertubular or intratubular have more mineralization

intra

70

Which; intertubular or intratubular, is a ring wider near the DEJ; accounting for narrowing of tubule

intra

71

This type of dentin is when the tubules are completely filled with intra/peritubular dentin

translucent or sclerotic dentin

72

This type of dentin is a normal process of aging

translucent

73

This type of dentin is accelerated deposition due to caries or attrition

sclerotic

74

This is when the tubules dry out and become filled with air

dead tracts

75

This is hypo mineralized dentin just below mantle dentin

interglobular dentin

76

The initial mineralization of dentin occurs in what

descrete foci

77

The individual foci can undergo calcification and become what

calcospherites; eventually fuse

78

If the individual foci do not calcify, what happens

becomes interglobular dentin

79

This is prominent in the crown

Tomes' granular layer

80

Where is there much interglobular dentin present

in DSPP knockout mice

81

Growth lines in dentin represent what

incremental pattern of deposition