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May14 Oral Histology > EX2; Dentin/Pulp Complex 1 > Flashcards

EX2; Dentin/Pulp Complex 1 Flashcards

1
Q

This the soft connective tissue in the tooth center with blood vessels and whole cells

A

pulp

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2
Q

Is the pulp mineralized or non-mineralized

A

non-mineralized

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3
Q

This is the mineralized connective tissue covering the pulp with no blood vessels or whole cells

A

dentin

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4
Q

What two things does dentin contain in the tubules

A

odontoblastic process

nerve endings

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5
Q

What is the main clinical significance of dentin

A

protective of both enamel and pulp

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6
Q

This feature of the DEJ facilitates adhesion

A

scalloping

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7
Q

When does dentinogenesi begin

A

during the bell stage

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8
Q

Just prior to dentinogenesis, what occurse

A

tissues layers of dental organ present
crown outline present
no odontoblasts or ameloblasts

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9
Q

In which part of the tooth germ does dentinogenesis begin

A

the most coronal portion

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10
Q

Where does the inductive signal for odontoblast differentiation come from

A

the enamel organ

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11
Q

What is the main signaling molecule/growth factor controlling odontogenesis

A

Wnt10a

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12
Q

This is a signaling molecule that follows Wnt10a; is induced by this

A

dentin/odontoblast specific marker; DSPP

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13
Q

The odontoblast secretes this first then it is mineralized

A

organic matrix then its mineralized

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14
Q

What is the name of the unmineralized organic matrix of dentin

A

predentin

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15
Q

What are the requirements for mineralization

A

Ca2+ and phosphate

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16
Q

Where does the phosphate come from used for mineralization

A

from plasma and cleavage of organic containing phosphate transported into dentin through and between odontoblasts

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17
Q

What are the two sections of crystal formation

A

mantle

circumpulpal

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18
Q

What is the principal component of the organic matrix of mantle dentin

A

collagen type 1

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19
Q

What are the sizes of the collagen fibrils in mantle dentin

A

relatively large

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20
Q

What is the orientation of the mantle dentin fibrils

A

at right angles to the basal lamina/future DEJ

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21
Q

Near the end of mantle dentin formation, what occurs

A

one dentin process becomes dominant

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22
Q

What is different about the circumpulpal dentin compared to mantle dentin

A

smaller fibrils

parallel to basal lamina

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23
Q

Where does the mineralization come from in circumpulpal dentin

A

not matrix vesicles, it comes from proteins

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24
Q

What is circumpulpal dentin synthesized from

A

synthesized and secreted from odontoblastic process (along with ions)

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25
Special properties of the proteins involved in circumpulpal dentin formation
they precipitate Ca2+ ions preset in the interstitial fluid, initiate crystal formation
26
Which dentin is more organic
mantle dentin
27
Which dentin is more mineralized
circumpulpal dentin
28
The DEJ is more vulnerable to what
caries
29
How specific is phosphophoryn/dentin phosphoprotein
relatively specific to dentin
30
What is the prominent dentinal protein
>50% non-collagenous proteins (NCPs)
31
What constitutes to the negative charge of phosphophoryn/dentin phosphoprotein
highly phosphyorlated high in serine/aspartic acid acidic/anionic
32
What is the percentage of organic, inorganic, and water of dentin by WEIGHT
``` inorganc = 70% (HA) organic = 20% water = 10% ```
33
What is the percentage of organic, inorganic, and water of dentin by VOLUME
``` inorganic = 45% organic = 33% water = 22% ```
34
What is the only physical property that dentin is greater than enamel at
compressive strength
35
What is orientation of the hydroxyapatite crystals
random orientation
36
What makes up the extracellular matrix of the organic phase of dentin
collagen | non-collagenous proteins
37
What are the non-tissue specific proteins that make up the organic phase of dentin
proteoglycans | signaling molecules/growth factors; bone morphogenetic protein
38
What are the mineralized-tissue specific proteins that make up the organic phase of dentin
osteoclastin | bone sialprotein
39
What are the dentin dominant proteins that make up the organic phase of dentin
dentin matrix protein 1 dentin glycoprotein dentin sialoprotein
40
What type of long chain does dentin phosphoprotein contain
polar amino acid repeats greater than 200 serine-serine-aspartic acid phosphorylated serines
41
What would occur is DSPP is mutated (abnormal)
it cannot be released from the odontoblast; stick in the rER or cell membrane
42
What are the changes at the genetic level from a D1 mutation in DSPP
changes in the first three amino acids; iso, pro, val
43
Is the D1 DSPP mutation dominant or recessive inheritance
dominant
44
What is the result in the coding region of DSPP under a D1 mutation
small base pair deletions that produce frame shifts changing the polar amino acid repeats to uncharged
45
mutates DSPP also affects the normal protein made by the cell how
by trapping it
46
What type of mutation is D1 DSPP
dominant negative
47
What is the result if a cell begins to have more DSPP mutatnts
less DSPP is secreted
48
What are the contents of the dentinal tubules
``` fluid; major component = water nerve fibers odontoblastic processes less collagen fibers non-cellular lining sheath although organic composition is unknown ```
49
How are the dentinal tubules in relation to the DEJ
at right angles
50
What is the shape of the dentinal tubules
S-shaped at the crown | straighter in the root
51
What type of branching pattern does the dentinal tubules have
terminal and lateral branches
52
Does inner or outer dentin contain more tubules
inner dentin
53
What is the pattern of depth in the dentin
the number continues to decrease in outer dentin | deep > middle > outer
54
Does inner or outer dentin contain larger tubules
the diameter of tubules is larger in inner dentin
55
Where do the tubules occupy less surface area, at the DEJ or the P-D border
DEJ
56
What increases toward the P-D border
permeability and wetness
57
This dentin formed until the completion of root development
primary dentin
58
True or False | primary dentin does not comprise most of the dentin
False; it does
59
What are the two types of primary dentin
mantle | circumpulpal
60
Which is more mineralized, mantle or circumpulpal dentin
circumpulpal
61
This dentin forms after root development and is formed at a slower rate but throughout life
secondary dentin
62
Where is secondary dentin in relation to primary dentin
central
63
What are the similarities between primary and secondary dentin
similar in structure | also classified as circumpulpal dentin
64
This dentin is produced in specific locations in response to noxious stimulus
tertiary dentin
65
What is the structure of tertiary dentin
structurally irregular may or may not have tubules may include cells
66
Where is both intertubular and intratubular dentin found
in primary and secondary dentin
67
Where is intertubular and intratubular dentin found in relation to the tubules
``` inter = between intra = lining ```
68
Does intertubular or intratubular have a greater volume
inter
69
Does intertubular or intratubular have more mineralization
intra
70
Which; intertubular or intratubular, is a ring wider near the DEJ; accounting for narrowing of tubule
intra
71
This type of dentin is when the tubules are completely filled with intra/peritubular dentin
translucent or sclerotic dentin
72
This type of dentin is a normal process of aging
translucent
73
This type of dentin is accelerated deposition due to caries or attrition
sclerotic
74
This is when the tubules dry out and become filled with air
dead tracts
75
This is hypo mineralized dentin just below mantle dentin
interglobular dentin
76
The initial mineralization of dentin occurs in what
descrete foci
77
The individual foci can undergo calcification and become what
calcospherites; eventually fuse
78
If the individual foci do not calcify, what happens
becomes interglobular dentin
79
This is prominent in the crown
Tomes' granular layer
80
Where is there much interglobular dentin present
in DSPP knockout mice
81
Growth lines in dentin represent what
incremental pattern of deposition

May14 Oral Histology (25 decks)

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