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Flashcards in Exam 1 Deck (22):
1

IL-5

cells affected: Eosinophils

2

IL-11

megakaryocyte produciton

3

Thromboprotien (TPO)

RBC and megakaryocyte/produced in liver receptor is
c-Mpl

4

Erythroprotein (EPO)

RBC's produced in kidneys Kidney failure=low RBC
Acitivated EPO recepotor=antiapoptotic

5

A antigen whats added

N-aceytlgalactosamine

6

B antigen whats added

Galactose by galactose transferase

7

Factors for anemia

def in B12 /B9/ Iron

8

Microcytic vs macrocytic anemia

Mic=small RBC's Fe def
Mac=Def B9/B12 large volume

9

Clotting cascade

damaged Epithelium-> release serotonin, thromboxane A2, ADP-> activated granules secrete thromboplastic factor-> fibrinogen to fibrin on glycocalyx->lysed by Plasmin->plateletes release PDGF alpha granules which aid in tissue repair

10

IL-4/13

basophils and mast cells

11

IL-7

Lyphocyte production/produced by stromal cells

12

X-linked skid

decreased t cells missing part of IL-7 receptor

13

Alpha Globin

Chromosome 16

14

Beta Globin

Chromosome 11

15

IL-3

expansion of meature hematopoietic cells/ produced by T-cells/Mast Cells/Eosinophils

16

What activates extrinsic pathway?

Tissue factor ( factor 3) (thromboplastin)-> factor 7

17

Intrinsic cofactors

8,9,11,12

18

extrinsic cofactors

3,7

19

vitamin K dependent factors

2,7,9,10

20

Kininogen function

helps factor 12 attach to neg surface

21

Kallikrein function

accelerates activation of 12

22

tenase

trimolecular complex in intrinsic pathway 8,9,ca