Organs of immune system
thymus
spleen
lymph nodes
tissue of the immune s
bone marrow
lympoid tissue
cells of the immune s
white blood cells
red blood calls and platelets
soluble factors
complement system antimicrobial peptides antibodies cytokines chemotoxic factors
primary lymphiod tissue
bone marrow
thymus
secondary lympoid tissues
spleen
lymph nodes and tissues
bone marrow
where most cells undergo maturation
tissue
thymus
where T cells undergo maturation
organ
lymph nodes and tissue
where immune cells are ready to respond
site of hematopoesis
bone marrow
GALT
gut associated lymphoid tissue
spleen
largest secondary lymphoid organ
traps antigens from circulation
2 spleen regions
red and white pulp
white pulp composition
composed of periateriolar lymphoid sheaths (PALs)
white pulp zones
T cell zone
B cell zone
marginal zone
red pulp
RBC cemetery
hematopoietic stem cell differentiates into
common lymphoid precursor OR common myeloid precursor
common lympoid precursor become
B cell OR NK/T cell precursor
B cell becomes
plasma cell
NK/T cell precursor becomes
T cell or NK cell
T cell becomes
Effector T cell
Plasma cell lineage
hematopoeitic stem cell –> common lymphoid precursor -> B cell -> plasma cell
Effector T cell lineage
hematopoeitic stem celll -> common lympoid precursor -> NK/t cell precursor -> t cell -> effector t cell
NK cell lineage
hematopoietic stem cell -> common lympoid precursor -> NK/ t cell precursor -> NK cell
common myloid precursor differentiates into
granulocyte macrophage progenitor OR megakaryocyte/ erythroid progenitor
megakaryocyte/erythroid progenitor differentiates into
megakaryocyte OR erthroblast
megakaryocyte to
platelets
erythroblast to
erythrocyte
granlocyte macrophage progenitor to
macrophage and dendritic cell precursor neutorphil eosinophil basophil unknown precursor to mast cells
macrophage and dendritic cell precursor becomes
monocytes and dendritic cells
monocytes become
macrophages and dendritic cells
platelets lineage
hematopoietic stem cell -> common myloid precursor -> MEP (megakaryocyte/erythoid precursor) -> megakaryocye -> platelets
erythrocyte lineage
hematopoitic stem cell -> common myloid precursor -> MEP (megakaryocyte/erythoid precursor -> erythroblast -> erythrocyte
Secondary lympoid tissues
trap antigens that come from mucosal surfaces via M cells
M cells
transport antigens to luminal lymphiod tissue via transcytosis
GALT details
well organized
includes: tonsils, adenoids, Peyers patches
BALT
broncial
MALT
mucosal
VALT
vaginal
LALT
larynx
blood makin’ in embios
yolk sac
blood makin’ around 4th month
fetal liver +spleen
blood makin’ after 4th monthish
bone marrow
effector B cells
plasma cells which make antibodies
effector T cells
include T helpers and cytotoxic T cells
T helpers
activate and regulate immune response
NK cells
cells of innate immunity, specialized for viruses
lymphoid lineage
NK cells
B cells
T cells
Myloid lineage
Neutrophils
Eosinophils
Basophils
monocytes
makrophages
dendritic cells
Mast cells
Megakaryocyte and erythroid lineage
erythrocyte
megakaryocyte
soluble factors of innate immun
complement
anitmictobial factors
acute phase proteins
soluble factors of adaptive
antibodies produced buy plasma cells
other soluble factors
cytokines
chemokines