Exam 1- Lectures 3 & 4 Flashcards Preview

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Flashcards in Exam 1- Lectures 3 & 4 Deck (38):
1

#1 cause of monogenic hypercholesterolemia

familial hypercholesterolemia (FH)

2

FH is

autosomeal co-dominant

3

FH class 1

no LDL receptors made

4

treatment for FH

HMG-CoA reductase inhibitors (statins)

5

what class can you not treat with HMG-CoA reductase inhibitors (statins) and why?

class 1- bc it requires at least some working receptors.

6

what kind of enzyme is NAT2?

phase II enzyme

7

NAT2 is

autosomal dominant

8

all NAT2 mutations are

SNPs

9

what is the function of NAT2?

detoxification/inactivation of xenobiotics by acetylation

10

slow acetylations due to NAT2 mutation increase risk of what cancers?

lung, liver, colon, bladder, non-hodgkin's lymphoma

11

slow acetylators:

increases toxicities

12

fast acetylators

decreases therapeutic effects

13

drug toxicity

drug induced anemia (G6PD enzyme)

14

drug efficacy

colorectal cancer (K-ras & EGFR)

15

what drugs can cause drug induced anemia due to GDPD

primaquine, salicylates, sulfonamides, nitrofurans, vitamin K derivatives

16

G6PD is

x-linked recessive

17

EFGR pathway

causes tumor proliferation if activated

18

what mutation can occur in tumor cells that makes it not respond to the receptor and be always activated ?

k- ras

19

a patient would not respond to anti-EGFR therapy if

the tumor has a k-ras mutation

20

pharmacokinetics is

what the body does to the drug
ADME

21

absorption

route of dose
first pass metabolism
active transport systems

22

distribution

protein binding
tissue barriers

23

metabolism

chemical structure changes in drug
phase I/phase II
P450

24

Elimination

kidneys/liver
milk
skin, hair

25

methods in identifying drug response phenotype

drug metabolism
drug receptors
drug transporters
biomarkers- efficacy & toxicity
disease susceptibility

26

major pharmacogenomic considerations

intestinal wall/drug uptake
liver, first pass metabolism
food/water composition

27

decreased first-pass metabolism often leads to

increased drug bioavailability

28

alpha1-acid glycoprotein

mainly binding of basic drugs
ORM2- most important; major source of variability in the binding of basic drugs

29

C3435T mutation

causes reduced levels of P-gp & higher plasma [] of drugs transported through P-gp

30

P-gp is a biomarker for

drug resistance & prognosis in cancer patients

31

P-gp is a target for

novel anticancer agents

32

multiple drug resistance protein (MRP) transport what?

acids

33

organic acid transporter (OAT) transports

organic acids

34

Organic anion transporting polypeptide (OATP) transports

lipophilic agents

35

organic cation transporter (OCT) transports

efflux of cations

36

test 1=

required

37

test 2=

recommended

38

test 3=

info only