EXAM 1: SPLEEN

Question 1

WHAT ARE DIFFERENTIALS FOR SOFT, BLOODY, CAVITATED SPLEEN

Answer 1

Question 2

WHAT ARE DIFFERENTIALS FOR A FIRM, MEATY, SOLID SPLEEN?

Answer 2

Question 3

Answer 3

LYMPHOID HYPERPLASIA

Question 4

SPLENOMEGALY W MEATY TEXTURE

Answer 4

CHRONIC IMHA

Question 5

SPLENOMEGALY W MEATY TEXTURE

Answer 5

AMYLOIDOSIS

Question 6

Answer 6

HEMANGIOSARCOMA

Question 7

Answer 7

HEMATOMA

Question 8

Answer 8

ACUTE INFARCTION

Question 9

Answer 9

ACUTE INFARCTION

Question 10

Answer 10

HEMATOMA

Question 11

Answer 11

LYMPHOID NODULES HYPERPLASIA

Question 12

Answer 12

NODULAR LYMPHOMA

Question 13

Answer 13

SPLENIC STROMAL SARCOMA

Question 14

Answer 14

ABSCESSES - MYCOBACTERIOSIS

Question 15

Answer 15

ABSCESSES - TULAREMIA

Question 16

Answer 16

SIDEROTIC PLAQUES

Question 17

WHAT SPECIES ARE PRIMARILY AFFECTED BY ANTHRAX AND WHAT CAUSES THE DISEASE?

Answer 17

CATTLE AND SHEEP
BACILLUS ANTHRACIS

Question 18

WHAT IS THE SEQUENCE OF EVENTS CAUSING DISEASE WITH ANTHRAX?

Answer 18

SPORES ARE INGESTED, REPLICATED IN THE INTESTINAL TRACT, SPREAD TO LYMPH NODES, DISSEMINATE THROUGH BLOODSTREAM CAUSING SEPTICEMIA

Question 19

WHAT CAN BE SEEN ON IMPRESSION SMEARS OF THE SPLEEN OR BLOOD WITH ANTHRAX?

Answer 19

INTRAVASCULAR FREE BACILLI

Question 20

LIST CAUSES OF DIFFUSE FIRM ENLARGEMENT OF THE SPLEEN

Answer 20

MARKED PHAGOCYTOSIS AND PROLIFERATION OF CELLS (CHRONIC IMHA)
DIFFUSE GRANULOMATOUS DISEASE (CAN ALSO BE NODULAR)
EXTRAMEDULLARY HEMATOPOIESIS (CAN ALSO BE NODULAR)
NEOPLASIA (CAN ALSO BE NODULAR)
STORAGE DISEASE OR AMYLOIDOSIS

Question 21

RECALL 4 DIFFERENTIALS FOR SOFT/BLOODY, NODULES IN THE SPLEEN

Answer 21

HEMATOMAS
INCOMPLETE CONTRACTION
HEMORRHAGIC INFARCTS
HEMANGIOSARCOMA

Question 22

IN CONTRAST TO SOFT NODULES, WHAT ARE 3 DIFFERENTIALS FOR FIRM NODULES IN THE SPLEEN?

Answer 22

LYMPHOID AND COMPLEX NODULAR HYPERPLASIA
PRIMARY OR METASTATIC NEOPLASIA
GRANULOMATOUS OR ABSCESSATION
EXTRAMEDULLARY HEMATOPOIESIS

Question 23

WHAT IS THE TUMOR CELL TYPE OF HEMANGIOSARCOMA?

Answer 23

ENDOTHELIAL CELLS

Question 24

LIST 3 BREEDS THAT ARE COMMONLY AFFECTED WITH HEMANGIOSARCOMA

Answer 24

GOLDEN RETRIEVER
GERMAN SHEPHERD
LABRADOR RETRIVER

Question 25

WHAT ARE THE MOST COMMON PRIMARY SITES OF HEMANGIOSARCOMA?

Answer 25

SPLEEN
HEART (RIGHT AURICLE)
LIVER

Question 26

UNDERSTAND THE CAUSE OF CLINICAL SIGNS IN HEMANGIOSARCOMA

Answer 26

TUMORS CAN RUPTURE AND CAUSE BLEEDING INTO ASSOCIATED CAVITY
WEAKNESS, DISTENDED ABDOMEN, PALE GUMS, AND COLLAPSE DUE TO HYPOVOLEMIA OR CARDIAC TAMPENADE

Question 27

RECOGNIZE GROSS CHANGES SEEN WITH HEMANGIOSARCOMA, HEMATOMAS AND HEMORRHAGIC INFARCTS

Answer 27

ALL HAVE SOFT, BLOODY NODULES

Question 28

IN CONTRAST TO SOFT NODULES, LIST DIFFERENTIALS FOR FIRM NODULES IN THE SPLEEN

Answer 28

LYMPHOID AND COMPLEX NODULAR HYPERPLASIA
PRIMARY OR METASTATIC NEOPLASIA (CAN BE DIFFUSE)
GRANULOMAS OR ABSCESSATION
EXTRAMEDULLARY HEMATOPOIESIS

Question 29

SELECT AT LEAST 2 BACTERIA, FUNGAL AND PROTOZOAL DISEASES THAT CAN CAUSE GRANULOMATOUS OR PYOGRANULOMATOUS DISEASE IN THE SPLEEN

Answer 29

BACTERIA: MYCOBACTERIUM, TULAREMIA, YERSINIA, BUCELLA
FUNGAL: BLASTOMYCES, HISTOPLASMA, COCCIDIOIDES, SPOROTRIX
PROTOZOA: TOXOPLASMA, NEOSPORUM

Question 30

WHAT IS THE CELL OF ORIGIN OF HISTIOCYTIC SARCOMA?

Answer 30

CUTANEOUS: LANGERHANS CELL
TISSUE: INTERSTITIAL DENDRITIC CELL
SPLEEN: HEMOPHAGOCYTIC SPLENIC MACROPHAGE

Question 31

WHAT ARE COMMON TISSUES THAT CAN BE AFFECTED WITH HISTIOCYTIC SARCOMA?

Answer 31

SKIN, LUNG, MENINGES, LYMPH NODE, BONE MARROW, SYNOVIUM

Question 32

WHAT ARE COMMON BREEDS AFFECTED WITH HISTIOCYTIC SARCOMA?

Answer 32

BERNESE MOUNTAIN DOG
GOLDEN RETRIEVER
ROTTWEILER
FLAT-COATED RETRIEVER

Question 33

WHAT IS THE CELL OF ORIGIN OF HEMOPHAGOCYTIC HISTIOCYTIC SARCOMA?

Answer 33

MACROPHAGES OF SPLEEN AND BONE MARROW

Question 34

DESCRIBE SIDEROTIC PLAQUES

Answer 34

ROUGH, BROWN TO YELLOW PLAQUES ALONG THE SEROSAL SURFACE