Exam 1; Susceptibility to Periodontal Diseases Flashcards Preview

AU14 Periodontology > Exam 1; Susceptibility to Periodontal Diseases > Flashcards

Flashcards in Exam 1; Susceptibility to Periodontal Diseases Deck (28):
1

What is the definition of susceptibility

it is the state of being easily affected, influenced, or harmed by something

2

Different forms of periodontitis may gave different what

etiological factors

3

What is meant by saying that periodontitis is a clinical diagnosis

There is no "test" for periodontitis, you diagnose it similar to caries diagnosis

4

What three things lead to periodontal inflammation

genetic modifiers
specific bacteria
environmental modifiers

5

These activate the mechanism in the periodontal tissues that lead to inflammation

bacteria

6

The magnitude and quality of periodontal tissue changes are determined not only by the bacteria but what else

by the patient's genetics and environmental modifiers such as smoking

7

The net result of the bacteria and genetic/environmental modifiers produces what

the clinical severity of disease

8

Periodontal diseases are what type of infections

specific mixed infections; does not follow Koch's postulats

9

Periodontal diseases cause periodontal destruction in which type of host

the appropriately susceptible host

10

True or False
Periodontopathic bacterial flora is necessary but not sufficient for disease

True

11

What is the odds ratio environmental risk factor of smoking and periodontitis

2.5-3.7

12

What is the odds ratio environmental risk factor of diabetes and periodontitis

2.8-3.4

13

What type of genetic modifier example falls under Mendallian inheritance

a single gene autosomal gene causes heredity gingival fibromatosis

14

What type of genetic modifier examples falls under chromosomal disorder

Down Syndrome; trisomy 21
Turner Syndrome; only one X chromosome

15

What type of genetic modifier example falls under complex gene disorders

things like cardiovascular disease, diabetes mellitus, and destructive periodontal diseases

16

What type of genetic modifier example falls under polymorphisms

two or more different phenotypes exist within different individuals

17

What type of genetic modifier example falls under SNPs

it is the difference of a single nucleotide; sickle cell anemia

18

What three things can complex gene disorder involve

mutlifactoral (polygenic) interactions
gene-gene interactions
gene-environment interactions

19

True or False
The contribution of any single factor is sufficient to cause disease

False; the contribution of any single factor alone is not sufficient to cause a disease

20

True or False
Multiple genes and environmental factors contribute collectively to cause a disease

True

21

What are the five characteristics of complex gene traits

common in the population
no clear familial transmission
adult age onset
environmental factors etiological too
combination of multiple small genetic and environmental factors

22

True or False
There is evidence that multiple different genes are important in periodontitis

True (genetic heterogeneity)

23

Genetic pre-disposition may act through what three different mechanisms

structural defects
immune response defects
WBC defects

24

True or False
There are a few genetic polymorphisms reported with periodontitis

False; there are MANY!

25

This type of relationship is very difficult to prove for complex genetic diseases

cause and effect

26

This will not be diagnostic for a complex gene disease

SNP

27

What are the four reasons that an SNP will not be diagnostic for a complex gene disorder

no single gene contributes enough to CAUSE disease alone
environmental factors are important/required to cause disease
need to study many people in standardized way to identify an association between SNP and disease state
human populations are mixed in terms of gene polymorphisms and environmental exposures

28

Evidence supports this model involving periodontits

complex genetic model involving gene-gene and gene-environmental interaction