EXAM 2 Cytokines Flashcards Preview

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Flashcards in EXAM 2 Cytokines Deck (47):
1

IL 2

T-Cell Proliferation and survival/ produced by activated T-Cells/clonal expansion t cells/B cells/necessary for t cell activation

2

IFN-Gamma

Activates macrophages/ produced by CD4+ & CD8+ t cells and NK cells/TH1/B cells to stimulate complement binding/ induces switch to Ig2a/viral infections/ increases expression of MHC class II

3

IL 4

B cell switching to IgE/ produced by CD4+ t cells and mast cells/stimulate and amplify TH2 response/ increase expression of MHC class II on B cells

4

IL 5

promote eosinophil production and activation/ Produced by CD4+ T cells, mast cells, innate lymphoid cells/TH2/ lead switch to IgA

5

IL10

Anti inflammatory/ suppresses the immune system sometimes produced by viruses to switch from th1 to th2 response

6

IL 17

Stimulation of acute inflammation/ produced by CD4 + t cells/ TH17/ chemoattractant for neutrophils and monocytes

7

IL 22

Maintenance of epithelial barrier function/ Produced by CD4+ T cells, mast cells, innate lymphoid cells/ TH17

8

TGF-Beta

Inhibition of T-cell activation/ produced by CD4+ t cells/anti inflammatory/Lead switch to IgA

9

IL 12

Induces T cells and NK cells to secrete IFN gamma

10

IL 13

stimulate and amplify TH2 response

11

TNF-ALPHA

take out RBC's vascular depletion, promotes inflammation, stimulates cytokine production, activates endothelium

12

IL1

take out RBC's vascular depletion

13

IL 3

multi lineage such as neutrophils basophils monocytes, promote eosinophil production and activation

14

IL 7

necessary of lymphoid cells t and b needed for t cell maturation/ made by BM stromal cells, fribroblasts

15

IgA

Mucossol immunity/ first line of defense/transport across epithelium/ main neutralizer at mucosal

16

IgD

naive B cell antigen receptor/sensitization of basophils

17

IgE

Immediate hypersensitivity / defence against helminthic parasites/ allergic response/ stimulates Fc receptors on mast cells/ released by plasma cells

18

IgM

Naive B cell antigen receptor/ compliment activation/can be expressed without isotype switching

19

IgG

opsinization compliment activation/ antibody dependant cell mediated cytotoxiticy/ neonatal immunity comes through placenta/feedback inhibition of b cells/ most common in blood/ memory immunity/ main nuetralizer in tissues

20

TH1 cells

Produce IFN-gamma/TNF-alpha/ activate macrophages/ inflamation differentiation induced by IL 12 IFN-gamma

21

TH2

Produces IL 4/5/9/10/13 humoral immunity activation/ allergies targets eosinophils/ differentiation induced by TSLP/triggers alterantive macrophage activation leading to reduced inflamation

22

TH17

produces IL 17-/IL22 host defense and pathogenesis of autoimmune/ neutrophillic inflammation/ differentiation induced by TGF-beta IL 6 IL1 IL23 GMCSF/ maintain gut tolerance

23

Tregs

cd4+ use CDLA4 to inhibit t cells

24

Mast cell Enzymes: tryptase chymase, cathepsin G, carboxypeptidase

remodeling of connective tissue matrix

25

mast cell-toxic mediator histamine heparin

toxic to parasites, increase vascular permeability, cause smooth muscle contraction

26

mast cell release GM-csf

promote eosinophil production and activation

27

CCL3

chemotactic for monocytes, macrophages and neutrophils

28

Lipid: Leukotrienes C4, D4, E4

cause smooth muscle contraction, increase vascular permeability, cause mucus secretion

29

Lipid: platelet activating factor

chemotactic for leukocytes, amplifies production of lipid mediators, activates neutrophils eosinophils and platelets

30

major basic protein:

triggers histamine release from mast cells

31

Person lacking antibodies susceptible to what kind of infection by what

encapsulated bacteria cant opsinize/enteroviruses

32

Rotarvirus vac

RV

33

chikenpox vac

varicella

34

polio vac

IPV/ live attenuated virus

35

Phneumococcal vac

PCV

36

BCG or cholera Vac

Live attenuated or killed bacteria

37

tetanus/diptheria vac

subunit vaccine

38

Haemophilus influenzae vac

conjugate vaccine helper t cell response to polysaccharide antigens

39

Hep virus vac type

sythetic vaccine

40

stepcocci phneumonia vac

conjugate vaccine

41

Rotavirus

infant diarrea

42

desensitization immunotherypy

decrease th2 increase th1, increase t regs

43

rituximab

drug against cd 20 depletes b cells used for AI and RA/ non hodgkins

44

Adalimumab (humira)

used for RA bloacks TNF-alpha

45

Thymic epithelium express which HLA mostly?

class II and smaller class I

46

Liver and KIdney, neutrophils cells express which HLA

class I only

47

Enzyme TdT function

junctional diversity adds nucleotides