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Flashcards in Exam 2 drugs Deck (43)
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1

abiraterone

selective CYP17 inhibitor - blocks late steroidogenesis step

2

spironolactone

androgen receptor antagonist

3

dexamethasone for PCOS?

decrease adrenal androgen synthesis

4

mifepristone

RU486 - progesterone receptor antagonist - loss of chorion, loss of hCG, lost of LH-like effect, loss of CL, loss of estrogen and progesterone, loss of child

5

what do you give with ketoconazole

replacement corticosteroid

6

tamoxifen

SERM - anti estrogen effect on breast (blocks interaction of ER and estrogen), stimulates endometrial growth

7

flutamide

androgen receptor antagonist

8

ganirelix

GnRH antagonist - no activation, no flare up, faster return to normal synthesis

9

what do you give with abiraterone?

prednisone

10

which has increased affinity for AR: bicalutamide or enzalutamide?

enzalutamide

11

raloxifene -

SERM - anti estrogen for breast, no effect on endometrium

12

leuprolide

GnRH agonist, can be used for PCOS, decreases LH production and ovarian androgen synthesis

13

ketoconazole

block early steroid synthesis

14

anastrazole

aromatase inhibitor - cancer chemotherapy

15

bicalutamide

androgen receptor antagonist

16

cyproterone acetate

AR antagonist - blocks testosterone and DHT binding - used to reduce hirsutism

17

disadvantage of cyproterone acetate

potential teratogen

18

disadvantage of glucocorticoid steroid (e.g. dexamethasone) for PCOS

cushing's-like syndrome possible

19

down side of aromatase inhibitors

may promote osteoporosis, may inhibit other P450 type enzymes

20

Fulvestrant

"pure" anti-estrogen - causes rapid ER degradation

21

thyroid storm BB

propranolol

22

finasteride

block 5 a reductase conversion of Testosterone to DHT

23

which is better tolerated: flutamide or bicalutamide?

bicalutamine, has less liver toxicity

24

oral contraceptive for PCOS

decrease LH production, decrease ovarian androgen synthesis

25

methimazole

thionamide - inhibits thyroid peroxidase

26

disadvantage of leuprolide

may increase risk of osteoporosis

27

dutasteride

block 5 a reductase conversion of Testosterone to DHT

28

enzalutamide

androgen receptor antagonist

29

danazol

for endometriosis - progeterone receptor antagonist

30

downside of danazol

pro-androgenic effect - manliness