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Flashcards in Exam 3 Deck (23):
1

Something is wrong with the gland (target organ)

primary pituitary disease

2

something wrong with hypothalamus (Rare)

tertiary pituitary disease

3

Something wrong in pituitary gland

secondary pituitary disease

4

CRF→ corticotrophs release

ACTH

5

TRF→ thyrotrophs release

TSH

6

FSH/LH-RF→ gonadrotrophs release

FSH/LH

7

GHRF→ somatotrophs release

GH

8

PIF (dopamine)→ lactotrophs inhibited from releasing

PL

9

______ is the most common anterior pituitary tumor

Adenoma

*prevalence of 16%

10

histology:
overgrowth of 1 cell type

adenoma

*normal has a mixture of cell types

11

Most common (30%)
Produces galactorrhoea and menstrual disturbances

Prolactinoma (chromophobe)

12

produces gigantism in children and acromegaly in adults (15%)

GH-secreting (esinophil)

13

Producings Cushings disease

ACTH-secreting (basophil)

14

No hormone production (27%)

null cell

15

how does pituitary adenomas produce clincal disease

1. excess hormone production
2. pressure/mass effect

16

sx of elevated intracranial pressure due to adenomas

Headache
nausea/vomitting

17

vision defects due to pressure/mass effect from adenomas

- can result in bitemporal hemianopsia

*pituitary is close to the optic chiasm

18

anterior pituitary release what hormones

ACTH
GH
TSH
FSH, LH
Prolactin
MSH

19

posterior pituitary release what hormones

ADH aka vasopressin
Oxytocin

20

when does GH spike or get released

from deep sleep
*typically undetectable most of the day

21

GH raises ___

blood glucose levels

22

-Binds surface receptors on bone and fat
-Indirect action through IGF-I (somatomedin C)
-Leads to increased protein synthesis
-Accelerates breakdown of fat

GH

23

inhibited by undernutrition and hyperglycemia

GH