Exam 3: Ch 10 Lipid Synthesis & Intracellular Movement Flashcards Preview

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Flashcards in Exam 3: Ch 10 Lipid Synthesis & Intracellular Movement Deck (15):
1

order of lipid biosynthesis

water-soluble precursors assembled into membrane-associated intermediates

these are converted into membrane lipid products

2

cells synthesize new membranes only by...

expansion of existing membranes

3

fatty acids are assembled from...

two-carbon building block (acetate --> acetyl CoA) by several important enzymes

4

saturated FA enzymes

acetyl CoA carboxylase

fatty acid synthase

5

unsaturated FA enzyme

desaturase

6

site of lipid synthesis

smooth ER - cytosolic side

7

fatty acid binding protein (FABP)

bind FA for intracellular movement

8

FABP regulation

coordinate regulation with cellular requirements for uptake and release of FA

high in muscles using FA for making ATP and in adipocytes

9

golgi function in FA synthesis

adds head groups

ex. phosphorylcholine to sphingomyelin

10

after modification in the golgi, FA...

are transported to other cellular compartments through vesicle-medated mechanisms

11

flippases move ________ from one leaflet to the other

phospholipids

requires ATP

12

cholesterol is synthesized by enzymes in the ...

cytosol and ER membrane mostly in liver

HMG-CoA reductase (HMG-CoA to mevalonate) key step

13

HMG-CoA reductase is located

integral ER membrane protein

14

mevalonate is turned into other things by _____ enzymes

cytosolic

15

small lipid transfer proteins facilitate the exchange of _______ or ____ between different membranes

phospholipids, cholesterol