Exam 3: Neural Crest Flashcards Preview

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Flashcards in Exam 3: Neural Crest Deck (30):
1

Neural crest cells originate from the _____ _____ of the neural plate.

Lateral margins

2

Neural crest cells transform into mesenchymal from _____ cells.

Epithelial

3

What signals are expressed on epithelial side that prevent some epithelial cells from becoming neural crest cells?

BMPs & Wnts

4

What signal is expressed by the mesoderm to create neural crest cells?

FGF-8

5

What factors are important in allowing cells to break free for migration?

Snail-1, Snail-2, & Foxd3

6

The first emigrating neural crest cells take which path?

Ventral/sympathoadrenal path

7

The second emigrating neural crest cells take which path?

Ventrolateral path

8

The last wave of emigrating neural crest cells take which path?

Dorsolateral path

9

What are the 3 ligand/receptor pair guidance molecules?

Robo/Slit
Neuropilin/Semaphorin
Ephrin/Eph

10

T/F: Later migratory neural crest cells form spinal ganglia.

True

11

T/F: Early migratory neural crest cells can only form melanoblasts.

False, Late

12

What happens if you expose rat neural crest cells to glial growth factor in vitro?

They become schwann cells

13

How do single neural crest cells grown in culture compare to dye-injected neural crest cells in vivo?

Both produce progeny with 2 or more phenotypes

14

What happens if you transplant trunk neural crest cells into the cranial region?

Forms sympathetic and parasympathetic neurons instead of just sympathetic for the trunk and parasympathetic for the cranial region

15

What signals promote the differentiation of sympathetic neurons?

Phox-2 & Mash-1

16

In the sensory lineage pathway, _____ & _____ form sensory neurons, whereas _____ forms schwann cells

Wnt & Catenin
Glial growth factor

17

What factor/receptor duo is critical in the dispersal of premelanocytes?

Steel factor/c-kit

18

_____ is characteristic of melanocyte precursors.

Mitf

19

What inhibits neural crest cells from arising anterior to the diencephalon?

Dickkopf-1

20

T/F: Cells from R4 & posteriorly do NOT express Hox genes.

False, DO express Hox genes

21

Which Hox gene is expressed from R4 to pharyngeal arch 2 to prevent if from becoming the first arch?

Hoxa2

22

Which Hox gene is expressed from R6/R7 to pharyngeal arch 3?

Hox3

23

Neural crest cells from where form the cardia crest?

Somites 1-3

24

Neural crest cells from where make the vagal crest & parasympathetic innervation for the digestive tract?

R4-7

25

Which somites give rise to vagal neural crest?

Somites 1-7

26

Expression of what prevents trunk neural crest cells to enter the gut?

Slit-2

27

What do vagal crest cells not express that allows them to enter the gut?

Robo

28

Pax-3 mutations leading to pigmentation defects, deafness, cleft palate, & ocular hypertelorism are characteristic of what disease?

Waardenburg's syndrome

29

A deletion of chromosome 22 characterized by hypoplasia, reduced thymus, thyroid, & parathyroid function, and cardiovascular defects are characteristic of what disease?

DiGeorge syndrome

30

What is a common genetic disease manifested by multiple neural crest tumors on the skin?

Neurofibromas