Exam 4

Question 1

What was it used to be for?

Answer 1

Terfenadine (seldane)

Antihistamine

Question 2

Answer 2

Penicillin G

Question 3

Answer 3

Albuterol

Question 4

What are the states of Iron is each step of the CYP450 Cycle

A, B, C, D, E, F, G, H

Answer 4

Fe3+, Fe2+, O2-Fe2+, Fe3+ Peroxy state, Compund 0-Hydroperoxy form, Fe3+ but produces Fe4+, Fe4+, Fe3+

Question 5

Answer 5

Propranolol

Question 6

This was converted by an ______ to form this structure

Answer 6

Enalaprilat by Esterase

Question 7

Answer 7

Acetaminophen

Question 8

Describe Step C

What intermediate is formed?

Answer 8

• The reduced form of the complex binds to O2 to form Ferrus-Oxygen Intermediate

Question 9

Answer 9

Enalapril

Question 10

Answer 10

Phenytoin

Question 11

If somone is a Poor Metabolizer what % of a standard dose do they need?

IM?

EM?

UM?

Answer 11

• 50%
• 75% ish
• around >=100%
• >200%

Question 12

A poor metabilizer will have 2 copies of what CYP?

Answer 12

CYP2V6

Inactive

Question 13

Answer 13

Meperadine

Question 14

Answer 14

Lidocaine

Question 15

Step D

Answer 15

• Oxidation of Fe2+–>Fe3+
• Delivery of Second E-
• Formes peroxy state

Question 16

What enzyme converts R-warfarin into 10-hydroxywarfarin?

Answer 16

CYP3A4

Question 17

– Glucuronidases

– Sulfotransferases

– Glutathione transferases

These enzymes are found in what phase of metabolism?

Answer 17

In Phase II

Question 18

Answer 18

Terfenadine

Question 19

Answer 19

Warfarin

Question 20

Answer 20

heroin

Question 21

Answer 21

Diazepam

Question 22

Answer 22

Omeprazole

Question 23

Answer 23

Acrylamide

Question 24

Discribe Step A of the P450 Cyle

Answer 24

• Ferric (fe3+) CYP450
• Binds reversibly to A complex
• Displacement of H2O

Question 25

Answer 25

Aniline

Question 26

Answer 26

Probenecid

Question 27

CYP2C9 converts S-warfarin into?

Answer 27

6 and 7 hydroxy warfarin

Question 28

Answer 28

Benzo A pyrene

Question 29

Describe Step B In P450 Cylce

Answer 29

• Substrate complex undergoes reduction to ferrus by E- originating NAPDH-CYP450 Reductase

Question 30

CYP1A2 convert R-warfarin into?

CYP3A4?

Answer 30

• to 6 and 8-hydroxywarfarin
• 10 hydroxywarfarin

Question 31

Answer 31

Delta 9 Tetrahydrocannabinol

Question 32

What enzyme converts R-warfarin into 6 and 8 hydroxywarfarin?

Answer 32

CYP1A2

Question 34

Grapefruit Juice is a well known inhibitor of?

Answer 34

CYP3A4

Question 35

This is the active metabolite of what other drug?

It doesnt cross what?!

Answer 35

Fexofenadine (Allegra)

It is the active metabolite of Terfenadine

Doesnt cross the B.B.B.

Question 36

Answer 36

Enalaprilat

Question 37

Answer 37

Ciprofloxacin