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Flashcards in Exam 4 Deck (38):
1

What was it used to be for?

Terfenadine (seldane) 

Antihistamine 

2

Penicillin G

3

Albuterol

4

What are the states of Iron is each step of the CYP450 Cycle

 

A, B, C, D, E, F, G, H 

Fe3+, Fe2+, O2-Fe2+, Fe3+ Peroxy state, Compund 0-Hydroperoxy form, Fe3+ but produces Fe4+, Fe4+, Fe3+

5

Propranolol

6

This was converted by an ______ to form this structure 

Enalaprilat by Esterase 

7

Acetaminophen

8

Describe Step C 

What intermediate is formed?

  • The reduced form of the complex binds to O2 to form Ferrus-Oxygen Intermediate 

9

Enalapril

10

Phenytoin

11

If somone is a Poor Metabolizer what % of a standard dose do they need?

IM?

EM?

UM?

  • 50%
  • 75% ish
  • around >=100%
  • >200%

 

12

A poor metabilizer will have 2 copies of what CYP?

CYP2V6

Inactive 

13

Meperadine

14

Lidocaine

15

Step D 

  • Oxidation of Fe2+-->Fe3+ 
  • Delivery of Second E- 
  • Formes peroxy state

16

What enzyme converts R-warfarin into 10-hydroxywarfarin?

CYP3A4

17

–  Glucuronidases

–  Sulfotransferases

–  Glutathione transferases

 

These enzymes are found in what phase of metabolism?

In Phase II

18

Terfenadine

19

Warfarin

20

heroin

21

Diazepam 

22

Omeprazole

23

Acrylamide

24

Discribe Step A of the P450 Cyle 

  • Ferric (fe3+) CYP450 
  • Binds reversibly to A complex 
  • Displacement of H2O 

 

25

Aniline 

26

Probenecid

27

CYP2C9 converts S-warfarin into?

6 and 7 hydroxy warfarin

28

Benzo A pyrene

29

Describe Step B In P450 Cylce

  • Substrate complex undergoes reduction to ferrus by E- originating NAPDH-CYP450 Reductase

30

CYP1A2 convert R-warfarin into?

CYP3A4?

  • to 6 and 8-hydroxywarfarin
  • 10 hydroxywarfarin

31

Delta 9 Tetrahydrocannabinol 

32

What enzyme converts R-warfarin into 6 and 8 hydroxywarfarin?

CYP1A2

33

34

Grapefruit Juice is a well known inhibitor of?

CYP3A4

35

This is the active metabolite of what other drug? 

It doesnt cross what?!

Fexofenadine (Allegra)

It is the active metabolite of Terfenadine 

Doesnt cross the B.B.B. 

36

Enalaprilat

37

Ciprofloxacin

38