What was it used to be for?
What are the states of Iron is each step of the CYP450 Cycle
A, B, C, D, E, F, G, H
Fe3+, Fe2+, O2-Fe2+, Fe3+ Peroxy state, Compund 0-Hydroperoxy form, Fe3+ but produces Fe4+, Fe4+, Fe3+
This was converted by an ______ to form this structure
Enalaprilat by Esterase
Describe Step C
What intermediate is formed?
- The reduced form of the complex binds to O2 to form Ferrus-Oxygen Intermediate
If somone is a Poor Metabolizer what % of a standard dose do they need?
- 75% ish
- around >=100%
A poor metabilizer will have 2 copies of what CYP?
- Oxidation of Fe2+-->Fe3+
- Delivery of Second E-
- Formes peroxy state
What enzyme converts R-warfarin into 10-hydroxywarfarin?
– Glutathione transferases
These enzymes are found in what phase of metabolism?
In Phase II
Discribe Step A of the P450 Cyle
- Ferric (fe3+) CYP450
- Binds reversibly to A complex
- Displacement of H2O
CYP2C9 converts S-warfarin into?
6 and 7 hydroxy warfarin
Benzo A pyrene
Describe Step B In P450 Cylce
- Substrate complex undergoes reduction to ferrus by E- originating NAPDH-CYP450 Reductase
CYP1A2 convert R-warfarin into?
- to 6 and 8-hydroxywarfarin
- 10 hydroxywarfarin
Delta 9 Tetrahydrocannabinol
What enzyme converts R-warfarin into 6 and 8 hydroxywarfarin?
Grapefruit Juice is a well known inhibitor of?
This is the active metabolite of what other drug?
It doesnt cross what?!
It is the active metabolite of Terfenadine
Doesnt cross the B.B.B.