Exam 4; Cancer Chemotherapy Flashcards Preview

AU14 Pharmacology > Exam 4; Cancer Chemotherapy > Flashcards

Flashcards in Exam 4; Cancer Chemotherapy Deck (58)
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1

What is the definition of neoplasia

uncontrolled growth of cells

2

What are three treatments of neoplasias

surgery
radiation
pharmacologic agents

3

Non-specific cancer agents act on what

all cell phases of replication and resting

4

Cell specific cancer agents act on what

all cell that are replicating rapidly

5

Cell specific cancer agents act on more defined sites like what

antimetabolites
mitotic spindle inhibitors
enzyme inhibitors

6

What is the broad scope of cell cycle non-specific agents

alkylating agents

7

What is the mechanism behind the alkylating non-specific agents

adding an alkyl group to DNA, causing DNA cross linking and inhibits cell replication and RNA synthesis

8

What is the mechanism behind cyclophosphamide

pro-drug given orally or IV
when it kits the cell/DNA it stops the cell from working

9

What type of drug is lomustine

pro-drug given IV; alkylating agent

10

What are some side effects of cisplatin

renal damage and ototoxicity

11

What type of drug is cisplatin

alkylating agent

12

What is the mechanism behind doxorubicin

inserts itself into DNA and blocks DNA and RNA synthesis

13

Doxorubicin and other rubicin's produce these

free radicals; can break DNA strands

14

Doxorubicin can cause this to occur

heart muscle degeneration (due to the free radicals)

15

How is doxorubicin given

IV

16

What is the mechanism behind dactinomycin

intercalates with DNA and interferes with mRNA synthesis

17

What is the mechanism behind bleomycin

intercalates with DNA and causes DNA strand breakage

18

What can result from bleomycin

pulmonary fibrosis

19

What is the mechanism behind cell cycle specific agents

block the specific enzymatic pathways in DNA synthesis; inhibit cell synthesis; ENZYME INHIBITORS

20

What is the mechanism behind methotrexate

inhibits dihydrofolate reductase

21

Methotrexate can cause this to happen

myelosuppression (bone marrow)

22

What can be used to treat the side effect caused by methotrexate

giving leucovorin, which is a THFA analog; which can resume normal cells but not malignant

23

What is the mechanism behind 5-flurouracil

it inhibits thymidylate synthase; inhibit thymidine synthesis

24

What is the mechanism behind cytarabine

inhibits DNA polymerase

25

What type of drugs are 5-flurouracil and cytarabine

pyrimidine analogs

26

What is the mechanism behind 6-mercaptopurine

its converted to an analog that inhibits several enzymes needed for purine synthesis

27

What type of drugs are the pyrimidine and purine analogs

pro-drugs

28

What is the mechanism behind vincristine and vinblastine

binds to microtubules and blocks cell mitosis; given IV

29

What is the mechanism behind paclitaxel and the other "taxel's"

forms abnormal microtubules

30

What is the mechanism behind Eribulin

inhibits microtubule and prevents mitosis; causing apoptosis