Exam 6

Question 1

what is this and what does it show CD19 20 positive or negative

Answer 1

reed sternberg cell shows hodgkins lymphoma

negative

Question 2

what is this and what does it show

Answer 2

russel bodies in plasma cells - shows plasma cell neoplasm dyscrasis multiple myeloma
- monoclonal gamma globulin

Question 3

Th1
-cell surface glyco proteins
-secretions

Answer 3

cell surface glyco proteins: CD4 and TCR
-secretions: Interluekin 2
IFN gama

Question 4

Th2
-cell surface glyco proteins
-secretions

Answer 4

cell surface glyco proteins: CD4 and TCR
-secretions: Interluekin 4
&5

Question 5

Tc
-cell surface glyco proteins
-secretions

Answer 5

cell surface glyco proteins: CD8 CD95L TCR
-secretions: Perforin Granzyme

Question 6

Tr
-cell surface glyco proteins
-secretions

Answer 6

cell surface glyco proteins: CD4 CD25 TCR
-secretions: Inter luekin 10

Question 7

Somatic Recombination occurs on the alpha chain of the TCR and at what stage (pro, pre, immature, mature)

Somatic Recombination occurs on the beta chain of the TCR and at what stage (pro, pre, immature, mature)

what cell is double positive (pro, pre, immature, mature)

Answer 7

alpha chain in the pre T
beta chain in the pro T
immature

Question 8

mature cells hace what CD

Answer 8

CD 4 or CD 8

Question 9

what binds to CTLA-4 and what does it do when it bind

Answer 9

CTLA-4 on the t cell binds to B7 to stop proliferation

Question 10

what binds to cd28

Answer 10

CD28 is on T cell and it binds to B7 on the APC cell to cause proliferation

Question 11

Explain the activation/ maturation of T cells

Answer 11

Question 12

Cancer pt are given ____ to make agressive T cell

Answer 12

IL 2

Question 13

inhibiting NFAT does what

Answer 13

causes immuno supression no proliferation activation of T cells —- cyclosporins

Question 14

what starts proliferation of T cells … aka what binds to start proliferation

Answer 14

IL 2

Question 15

what causes the cell to produce cyclins

Answer 15

IL 2 to IL2 receptors

Question 16

after proliferation what two types of t cells are produced (which are shorter lived)

Answer 16

effector (shorter lived)
memory T (long lived)

Question 17

draw types of effector Helper cells and what they secrete

Answer 17

Question 18

what cells have FAS receptor and what cell hav FASL

Answer 18

all nucleated cells have FAS
CTL cd8 + bind to it

Question 19

what is released if macrophage cant digest something and what does this activake

Answer 19

IL 12
activate NK cells

Question 20

what is the first line of defense in viruses,
what does this cause
innate or adaptive

Answer 20

inhibition of intfection by releasing INF-a IFN-B
* antiviral mech
* increase MHC 1exp
* stimulate NK

innate

Question 21

what activates NK

Answer 21

-INF beta and alpha
-IL12
-IL 15

Question 22

sti

Central memory and effector memory difference

Answer 22

central
* secondary lymph tissue
* proliferate quick
Effector
* peripheral
* cecrete cytokines
* DONT PROLIFERATE

Question 23

which cells express CD19
which cells express heavy chain and surrogate

Answer 23

proB cells which is the eliest
pre- b

Question 24

where does positive selection occur for B cells

Answer 24

periphery

Question 25

what is anergic and what cells become this

Answer 25

unresponsive cells thtat show low levels of IgM b cells with weak interaction to cell antigen

Question 26

what cells become clonally ignorant

Answer 26

self reactive but done respond have ig D and IGM

Question 27

what needs to bind so that way B cells activate

Answer 27

ag to BCR (Th2)TCR to MHC 2 (Th2) CD40L to CD40

Question 28

what cells show CD21

Answer 28

mature B cells

Question 29

what is peripheral tolerance

Answer 29

mechanisms to get rid of self reactive lymphocytes

Question 30

where does affinity maturation occur of b cell

Answer 30

germinal center

Question 31

name the iso type with the following Th1 Th2 Th17

Answer 31

Th1 IgG Th2 IgE Th17 IgA

Question 32

what is Hyper IGM syndrome

Answer 32

Mutation of CD 40 L so no activation B cemm so Increase IGM and defective CMI cause NO MEMORY

Question 33

name the difference tumor specific ag (TSA): Tumor associated ag TAA:

Answer 33

tumor specific ag (TSA): * unique to tumor * cause immune resp Tumor associated ag TAA: * shared with normal cell type * done cause immune

Question 34

tumore tx as self ag- tollerance of tumor is done becuase.... antigenic modulation of tumor done by ...

Answer 34

no co stimulation eating ag

Question 35

what are TILS tumor infilrating lyphocytes and lyphokines activated killer LAKS

Answer 35

both are adoptive immunity to help cancer pt. lyphocytes are removed and tx with IL2

Question 36

what does rIFN alpha do

Answer 36

Increase MHC molecules and activate macrophage and NK

Question 37

what is conjugated Ab tx & unconjugated?

Answer 37

conjugated target delivery of toxins or drug to tumor with specific AG unconjugated: compliment based naked ab against tumor

Question 38

how do you turn a tumor cell into apc

Answer 38

make it exp by

Question 39

most common lymphoma type ? markers? non hodgkin or hodgkin

Answer 39

B cell Cd19 cd20

Question 40

Follicular lymphoma * type? * pain? * gene? * fast or slow progression * age of pt

Answer 40

Follicular lymphoma * type - b cell * pain -no pain * gene - BCL2 gene over expressed (anti apoptotic gene) * fast or slow progression: slow * age is middle years

Question 41

Diffuse large B cell lymphoma * type? * location? * fast or slow progression * age of pt

Answer 41

* type? b cell non hodgkin * location : tonsils throught orbit waldeyes ring, CNS in HIV * fast or slow progression: fast * age of pt around 60 * CNS in HIV patiens

Question 42

Burkitt lyphoma * marker? * microscopic view? * fast or slow progression * age of pt * what virus associated with this * translocation of

Answer 42

Burkitt lyphoma * marker? cd 19 20 * microscopic view? stary sky * fast or slow progression: aggressive * age of pt children * virus: EBV in african involving the maxilla and non ebv in abdominal organs in adults * translocation of 8:14 with MRC activated

Question 43

Mantel cell * what type of lyphoma * px? * age of pt

Answer 43

Mantel cell * what type of lyphoma: B cell * px? poor prognosis * 50 MALES

Question 44

what dz is associated with MALToma

Answer 44

* infection and inflamation * sjogrens and heliovacter pylori * can be fixed

Question 45

Mycosis funguicides * cell type of lyphoma * name phases

Answer 45

* cell type of lyphoma Th cd4+ Sezary cells * name phases * resembles fungal infection

Question 46

Adult T cell Luekemia is caused by ____ virus that makes ____ neoplams

Answer 46

Adult T cell Luekemia is caused by __ HTLV1__ virus that makes __ CD4 Th__ neoplams

Question 47

what virus causes extranodal NK t cell lyphoma

Answer 47

EBV causeing necrotizing neoplasm

Question 48

Mutiple myeloma * shows what in the blood? * what tests? * sx

Answer 48

* punched out bone * agressive * shows what in the blood? stacks of rbc , russle boddies * what tests? emce jones protein causes renal damage * bone pain and hyper calcemia

Question 49

What neoplams is associated with hyperviscosity agressive?

Answer 49

waldenstrom moderatly agressive IGM monoclonal

Question 50

what is the most agressive lymphoma

Answer 50

diffuse large B cell

Question 51

orbit lymphoma most likely

Answer 51

diffuse

Question 52

what is nodular sclerosis px? and age

Answer 52

most common form of hodgkin -young -good px

Question 53

dz associated with hodgkins lyphoma

Answer 53

HIV EBV

Question 54

Waldeye ring involved in nonhodgkin or hodgkin

Answer 54

non hodgkin

Question 55

what is it associated with .. * primary AL is primary amyloidosis , * secondary SAA

Answer 55

AL - multiple myoloma, enlarged tongue SAA - prolonged inflammation like RA