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Flashcards in Exam Two Deck (122)
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1

What structure contaisn 5NT and GGT?

bile duct epithelial cells

2

Bilirubin over what level can lead to jaundice?

2 mg/dL

3

WHat ezyme helps bilirubin get into the ER?

GST

4

What part of DNA is mutated in Gilbert Sydrome?

promoter

5

What is the mode of inheritance for CJ Type I and Type II?

Type I = AR

Type II = AD

6

What protein is defective during DJ Synrome?

MDR2

7

Presence of what molecule is used to Dx Dubin Johnson? Which isomer?

Total urinary coproporphyrins

Isomer 1

8

PFIC effects what cell type? What type of protein?

Epithelial

transporter

9

What is wrong in PFIC1?

canalicular ATPase

10

What is wrong in PFIC2?

bile salt export protein

11

What is wrong in PFIC3?

MDR3

12

According to Carnevale, what two drugs can cause hepatocellular dysfunction?

erythromycin

Chlorpromazine

13

What cell in the liver stores Vitamin A?

stellate

14

How many mm of Hg do manifestations of portal hypertension begin to occur?

12 mm Hg

15

What is the protein content during portal HTN?

> 1.1 g/dL

16

What is the peritoneal protein content during CHF?

17

What type of acidosis occurs during liver failure?

lactic

18

Do renal vessels undergo vasoconstriction or vasodilation during hepatorenal syndrome?

vasoconstriction

19

Does systemic circulation undergo vasodilation or vasoconstriction during HRS?

vasodilation

20

Which bacterial products are though to contribute to Hepatic Encephalopathy?

Mercaptans

21

What is the extrahepatic manifestation of HBV in children?

Glomerulonephritis

22

What is the extrahepatic manifestation of HBV in adults?

Polyarteritis Nodosa

23

What is the endocrine extrahepatic manifestation of HBV?

Hashimotos

24

What is the blood extrahepatic manifestation of HBV?

thrombocytopenia

25

What type of inflammation is seen during PBC?

granulomatous

26

What immunoglobulin would be present during PBC?

IgM

27

Anti-PDH-E2 is indicative of what liver diease?

PBC

28

What is the treatment for PBC?

Ursodeoxycholic acid

29

What cancer can PSC lead to?

Cholangiocarcinoma

30

What three antibodies are present during autoimmune hepatitis?

anti-ANA

anti-SMA

anti-LKM1