extracellular: collagen, elastin, wound healing Flashcards Preview

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Flashcards in extracellular: collagen, elastin, wound healing Deck (25):
1

purpose of collagen

strengthen the ECM

2

type I collagen

ONE = bONE (made by osteoblasts)
skin
tendon
dentin
scar tissue - late woundhealing

3

↓ production of this type of collagen in osteogenesis imperfecta

type I collagen

4

type II collagen

TWO = carTWOlage
cartilage
vitreous body (eye)
nucleus pulposus

5

type III collagen

BLOODY:
blood vessels
reticulin (skin)
uterus
fetal tissue
granulation tissue (shiny, red)

6

type IV collagen

basement memberane

7

vascular type of Ehlers-Danlos syndrome features

deficient type III collagen
arterial rupture
organ rupture
hemorrhage
easy bruising
berry aneurysm
aortic aneurysm

8

this type of collagen is defective in Alport Syndrome

type IV collagen

9

characteristics of keloid scars

LOTS of COLLAGEN synthesis
disorganized collagen arrangement
tx: glucocorticoid: inhibits collagen synthesis

10

osteogenesis imperfecta keywords

brittle bones → multiple fractures (may occur during birth, R/O CHILD ABUSE)
bowing of long legs in utero
blue sclera: see underlying choroidal veins
hearing loss: no ossicle bones of ME
no dentin

11

osteogenesis imperfecta

most common form = AD = OI type I
AR = OI type II = fatal in utero or after birth

12

classical type of ehlers-danlos syndrome features

mutated type V (mostly) + type I (some) collagen
hypermobility - joints → dislocated joints
hyperextensible skin

13

defect in fibrillin (glycoprotein that forms a sheath around elastin) causes this condition:

Marfan syndrome

14

features of Marfan Syndrome

tall
long arms/legs
arachnodactyly (spidery fingers)
hypermobile joints
heart valve problems
aortic dissection
lens dislocation
pectus carinatum - sternum protrudes anteriorly
+ steinberg sign: distal phalynx sticks out with a fist

15

locations of elastin (stretchy protein in extracellular matrix)

alveoli
arteries
vocal cords
ligamenta flava (connect vertebrae)

16

emphysema (panacinar) in young, non-smoker

α1 antitrypsin deficiency

17

α1 antitrypsin deficiency features

elastase breaks down elastin;
break down of elastin in alveoli → panacinar in young, non-smoker
accumulation of defective AT1 in hepatocytes → hepatitis, cirrhosis, hepatocellular carcinoma

18

mutation in this type of collagen in alport syndrome

type IV collagen - defective basement membrane

19

features of alport syndrome

can't see: cataract, lenticonus (thinning of capsule around lens)
can't pee: hereditary glomerulonephritis
can't hear a high C: sensorineural hearing loss

20

cutaneous wound healing:
0-3 hrs

hemorrhage + clot

21

cutaneous wound healing:
12-24 hrs

acute inflammation: neutrophils

22

cutaneous wound healing:
1-3 days

macrophages clear debris
granulation tissue (type III collagen): fibroblasts lay down collagen + vascular endothelial cells reestablish a blood supply
epithelialization (within first 48 hrs): epithelial cells migrate in

23

post-op bandages stay on for 48 hrs to allow for

epithelialization (occurs 1-3 days)

24

cutaneous wound healing:
wks - mos

type III collagen → type I collagen (scar, ↑ strength)

25

poor wound healing
anemia
swollen gums
bleeding

scurvy: vitamin C deficiency
no hydroxylation of proline + lysine of collagen → no collagen

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