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Flashcards in FA Deck (117)
1

MOA of memantine and what is it for?

NMDA blocker/Alzheimer's

2

MOA of cabergoline and what is it for?

D agonist like bromocriptine/hyperprolactinemia

3

Histology of hyperacute/acute/chronic transplant rejection>

Hyperacute--->thrombosis/DIC/vascular spasm
Acute--->vasculitis/lymphocyte infiltrate
Chronic--->fibrosis--->ischemia

4

Most overdose of what drug causes death in US?

Opioid

5

HoTN/Tachy/decrease RA pressure

Septic shock (fever might not be there if the pt is either old or immunocompromised)

6

C3a effect

Histamine release

7

Most common congenital heart defect

Bicuspid aortic valve

8

See a pt with an autoimmune disease

Think the possibility of having other autoimmune disease

9

Decrease bicarb comes with

Increase chloride

10

glutamate is excitatory or inhibitory?

Excitatory

11

Tetrabenazine

Huntington's (chlorea)/like reserpine

12

Milrinone MOA and effect

PDE3 inhibitor/increase contractility and vasodilate

13

Ranolazine

Decrease O2 consumption/angina

14

Adenosine

Increase K out of cell--->hyperpolarization
Terminate SVT

15

carbamazapine cause?

Aplastic anemia

16

Benzo used for short term anxiety

Lorazepam

17

Most common cause of death in DM pt

Cardiovascular disease

18

Coarctation of aorta associated with?

Cerebral hemorrhage (berry aneurysm)

19

See kid with viral infection (or adult)

think subsequent autoimmune disease like ITP

20

What is on chromosome 14

Ig heavy chain

21

Bortezomib

Proteasome inhibitor/Multiple myeloma

22

Cilostazol/dipyridamole

PDE3 inhibitors
Intermitten claudication/coronary vasodilation

23

Cell mediated vs. humoral \

Cell mediated--->macrophages (intracellular)
Humoral--->antibody/complement (extracellular)

24

Mu receptor MOA

Increase K efflux--->hyperpolarize

25

Rituximab

Anti CD20/anti B cell

26

Side effect of imatinib

Fluid retention

27

Trastuzumab

against HER2/cardiotoxicity

28

Causes of PCOS

Insulin resistance

29

Theca lutein cyst

Choriocarcinoma/moles

30

Ovarian tumor with fallopian tube epithelium

Serous cystadenoma

31

Ovarian tumor that grow in follicles and gland like with fluid in the middle

Granulosa cells (Call-Exner bodies)

32

Increase in placenta alka phos/fried eggs appearance

Seminoma

33

Increase AFP, what tumor

Yolk sac tumor

34

Period pain/heavy bleeding/uniformly enlarged uterus

Adenomyosis

35

endometrial mass with whorled pattern/sensitive to hormone/bleeding lead to iron deficiency anemia/equivalent in ovary?

Leiomyoma (endometrium)
Fibroma

36

Danazol

Androgen analog--->decrease FSH/LH--->endometrosis

37

Breast tumor with lymphocytic infiltrate

Medullary carcinoma

38

Peau d'orange

Inflammatory breast cancer--->block lymphatic drainage

39

Grandular/papillary mass in male testis/hemorrhagic

Embryonal

40

Testistical mass/gynecomastia

Leydig cell tumor

41

Thoracic aortic aneurysm

Cystic medial degeneration

42

Cushing triad

HTN/bradycardia/low RR--->increase ICP

43

Terbutaline

Beta 2 agonist--->relax uterus

44

Methadone

Full mu agonist/long half life

45

Immune complex/transmural inflammation/associated with hep B/livdo reticularis what kind of vasculitis?

Polyarteritis nodosa (medium size vessels)

46

associated with antibiotics, what kind of vasculitis?

Microscopic polyangitis

47

Essential tremor treat with

beta blocker

48

Chronic gastritis histology

lymphoid aggregates/atrophy

49

Menetrier disease

Muscosal cell hyperplasia (brain gyri)--->protein loss/decrease gastric acid

50

Pt with long term H.pylori infection came in complained of early satiety and weight lost

Intestinal gastric adenocarcinoma

51

ZE syndrome give rise to ___ ulcer

duodenal ulcer

52

Anterior/posterior ulcer

Anterior--->perforate
Posterior--->hemorrhage

53

anti endomysial

Celiac

54

decrease duodenal pH/fecal elastase

pancreatic insufficiency

55

Diverticuli MOA

Pulsion--->constipation (false)

56

Inferior phargyneal constrictor

Killian triangle--->zenker

57

Hirschsprung mutation

RET

58

Kids with viral infection, then GI problem

Appendicitis/intussusception

59

Postprandial pain

Chronic mesenteric ischemia

60

CEA

colon cancer marker

61

Fibrosis/regenerative nodule

Cirrhosis

62

shrunken liver

alcoholic cirrhosis

63

Rifaximin

treat hepatic encephalopathy

64

elevated AFP in GI, MC metastisize site

hepatocellular carcinoma/lung

65

Granulomatous destruction of intrahepatic duct

PBC

66

Causes for pancreatic cancer

Smoking/chronic pancreatitis/DM

67

Alkaline tide

Increase blood pH after gastric acid secretion

68

5HT

vasoconstrict/diarrhea

69

Post GI/urethritis infection

Reactive arthritis--->seronegative spondyloarthritis

70

Group A/B strep

Group A--->S. Pyogenes
Group B--->S. Agalactiae

71

Acamprosate

Alcoholic after they stop drinking

72

Hyperthroydism might have elevated

Beta hCG

73

Variable expressivity

AD

74

Tensor tympani/stapedius muscle innervated by

V3
VII

75

Neuroendocrine tumors (small blue cell)
APUD tumor

Pheo
Neuroblastoma
Medullary carcinoma of the thyroid
Small cell lung cancer
Carcinoid tumor

76

Neonate not developing well/umbilical hernia/big tongue

Think congenital hypothyroidism

77

After viral infection/granulomatous thyroid mass/tender

subacute granulomatous thyroiditis

78

Untreated hyperthyroid--->infection or trauma (stress)

Thyroid storm (tachy arrhythmia--->death)

79

Finely dispersed chromatin/thyroid mass

Papillary carcinoma

80

Pseudohypoparathyroidism/pseudopseudohypoparathyroidisim

Pseudo (defective Gs protein)--->hight PTH--->organ resistance to PTH--->low Ca--->knuckle knuckle dimple dimple
Pseudopseudo--->like pseudo but without organ resistance to PTH

81

Familial hypercalcemia hypocalcuric

Low Ca sensitivity (defective Ca sensing)--->excessive Ca renal reabsorption--->hypocalciuria

82

Pegvisomant

GH receptor antagonist

83

Anti glutamine acid decarboxylase antibodies

DM type 1

84

glucagonoma

Dermatitis (groin)/DM/depression/DVT

85

How to treat delirium?

Haloperidol

86

Tx for diptheria

Antitoxin (passive immunity)--->antibiotic--->active immunization

87

Aneuploidy

Abnormal number of chromosomes

88

Renal disease after an infection, kids

PSGN/minimal exchange

89

VU reflex/proteinaceous material in kidney/atrophic tubule

Chronic pyelonephritis

90

DIC/shock/placental abruption, what happen to the kidneys?

Diffuse cortical necrosis (infarction of both kidneys)

91

Renal failure consequences

High TG/inhibit conversion of T4 to T3--->functional hypothyroidism

92

Indapamide

Thiazide--->no high lipid

93

MC cause of diastolic heart failure

HTN

94

Leukemia that cause pancytopenia

Hairy cell/AML

95

Allergic triad

Rhinitis/dermatitis/asthma

96

Side effect of digoxin/promoted by

Cholinergic/yellow color vision/hyperK/arrhythmia
Renal deficiency and hypokalemia

97

MC malignant bone tumor

Multiple myeloma--->diaphysis

98

Bimodal age distribution/metaphysis of the bone

Osteosarcoma

99

Small blue cells/diaphysis of the bone/onion skin

Ewing sarcoma

100

Type of hypersensitivity for RA/lupus

Type III (IgM against Fc portion of IgG)

101

Gonococcal arthritis

Arthralgias/tenosynovitis/dermatitis (pustules)

102

Decrease in what is seen in lupus

C3/C4

103

Anti SRP/anti Mi 2 antibodies

Poly/dermatomyositis

104

Keratin cyst
Neutrophil in corneum
Target like
Hep C
Skin?

Seborrheic keratosis
Psoriasis
Erythema multiforme
Lichen planus

105

Leflunomide

Inhibit dihydrooroate dehydrogenase--->prevent pyrimidine synthesis--->suppress T cell proliferation
RA

106

Chlodiazepoxide

Benzo

107

Which vasculitis are granulomatous

Giant cell/Takayasu/Wegner/Churg Strauss

108

Father transmit to all daughters, MOI?

X linked dominate

109

sudden onset dyspnea

Think PE

110

Loud S2

Think about pul HTN or ASD

111

Lewy bodies

Contain alpha synuclein (eosinophilic)--->Parkinson

112

Tx for pseudomotor cerebri

Acetazolamide/weight lost

113

slow decrease in central vision/yellow deposit/tx?

Dry age related macular degeneration
Stop smoking/antioxidant

114

Child/calcification/cholesterol crystal/what brain tumor

Craniopharyngioma

115

Primitive small blue cell/brain tumor in kids?

Medulloblastoma

116

Corkscrew eosinophilic in kids brain tumor

Pilocystic astrocytoma

117

Vitamin B9

Folate