FA Bugs with Exotoxins I Flashcards Preview

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Flashcards in FA Bugs with Exotoxins I Deck (30):
1

Pharyngitis with pseudomembranes in throat and severe LAD (bull neck)

Corynebacterium diphtheriae

2

ADP ribosylating A-B toxin

Diphtheria toxin OR exotoxin A (pseudomonas)

3

What does the B component of the diphtheria toxin do?

(Binding) binds to host cell surface receptor, enabling endocytosis

4

What does the A component of the diphtheria toxin do?

(Active) attaches ADP-riboxyl to disrupt host cell proteins

5

What is the mechanism of diphtheria toxin?

Inactivate elongation factor (EF-2), thus inhibiting protein synthesis

6

With what bug is exotoxin A associated?

Pseudomondas aeuruginosa

7

What is the manifestation of exotoxin A action?

Host cell death

8

What is the mechanism of exotoxin A?

Inactivate EF-2 --> inhibit protein synthesis

9

What is the mechanism of Shiga toxin (ST)?

Inactivate 60S ribosome by removing adenine from rRNA

10

What does Shiga toxin do?

GI mucosal damage --> dysentery ST also enhances cytokine release, causing HUS

11

With what bug is Shiga-like toxin (SLT) associated

EHEC (incl O157:H7)

12

What is the mechanism of SLT?

Inactivate 60S ribosome by removing adenine from rRNA

13

What toxins inactivate 60S ribosome by removing adenine from rRNA?

Shiga and shiga-like toxins

14

What does SLT do?

Enhances cytokine release, causing HUS; unlike shigella, SLT does NOT invade host cells

15

What three bugs are associated with exotoxins that increase fluid secretion?

ETEC, bacillus anthracis, vibrio cholerae

16

What four bugs are associated with exotoxins that inhibit protein synthesis?

Diphtheria, Pseudomonas, Shigella, EHEC

17

What bug has a toxin that inhibits phagocytic ability?

Bordetella pertusis

18

What bugs have exotoxins that inhibit release of neurotransmitter?

Clostridium tetani, clostridium botulinum

19

What bugs have exotoxins that lyse cell membranes?

clostriudium perfringens,
streptococcus pyogenes

20

What bugs have exotoxins that are super antigens causing shock?

Staph aureus
Strep pyogenes

21

ETEC exotoxins

Heat-labile toxin (LT)
Heat-stabile toxin (ST)

22

bacillus antracis exotoxin

Edema factor

23

Vibrio cholerae exotoxin

cholera toxin

24

Bordetella pertussis exotoxin that inhibits phagocytic ability

Pertussis toxin

25

Clostridium tetani exotoxin that inhibits release of NT

Tetanospasmin

26

Clostridium botulism exotoxin that inhibits release of NT

Botulinum toxin

27

Clostridium perfringens exotoxin that lyses cell membranes

Alpha toxin

28

Strep pyogenes exotoxin that lyses cell membranes

Streptolysin O

29

Staph aureus exotoxin

TSST-1

30

Strep pyogenes exotoxin that is a super antigen causing shock

Exotoxin A (the same one as Pseudomonas?!)