Feline viruses

Question 0

What are characteristics of the retrovirdae viruses?

Answer 0

SS RNA, enveloped, have provirus state

Question 1

What are the 3 feline retroviruses?

Answer 1

FIV, Feline Leukemia, Feline Sarcoa

Question 2

How is FIV transmitted?

Answer 2

bites, milk from mother

Question 3

What are the 3 stages of FIV clinical symptoms?

Answer 3

1. Lymphadenopathy, fever
2. Long subclinical
3. progressive deterioation of health

Question 4

What are the common clinical signs of the last stage of FIV?

Answer 4

persistant fever, weight loss, gingivitis and stomatitis, loss of appetite, recurrent infections, behavior changes, neurological disorders

Question 5

How is FIV detected?

Answer 5

antibody by ELISA 8 to 12 weeks after infection- false positives
PCR - detecting PROVIRUS

Question 6

What are the 3 ways FeLV can cause disease?

Answer 6

1. Oncogenesis
2. Anemia/BM
3. Immunopathology

Question 7

How can the FeLV virus be detected?

Answer 7

PCR or hybridization even before it multiplies and releases

Question 8

Where are unclassified lymphsarcomas found in FeLV?

Answer 8

skin, eyes, CNS

Question 9

What are examples of immunopathological disease in FeLV?

Answer 9

uveitis, glomerulonephritis, lymphoid cells depletion, ADCC

Question 10

Which antigen is presented after FeLV transforms a host cell?

Answer 10

FOCMA - good for neutralizing antibody

Question 11

Which antigen of FeLV causes immune complex disease?

Answer 11

p27

Question 12

What characterizes a persistent active infection of FeLV?

Answer 12

lack of neutralizing Ab, constant shedding, lasts until death

Question 13

What characterizes a self-limiting infection of FelV?

Answer 13

becomes latent but not eliminated

Question 14

What is the hardy test?

Answer 14

immunofloursecence - detects p27 of FeLV

Question 15

How many tests for cat to have FeLV?

Answer 15

2 positive tests in 12 weeks

Question 16

How are latent infections of FeLV detected?

Answer 16

bone marrow culture and cell reactivation

Question 17

How might early transient FeLV show on tests?

Answer 17

positive to ELISA, negative by indirect IFA

Question 18

What is the most important way of transmission of FeLV?

Answer 18

saliva

Question 19

Is there a vaccine for FeLV?

Answer 19

yes, not 100% effective

Question 20

What are the clinical signs of feline sarcoma virus in kittens rarely?

Answer 20

fibrosarcoma, multifocal, metastic

Question 21

What virus does feline sarcoma virus need to replicate?

Answer 21

FeLV

Question 22

What family is feline infectious peritonitis?

Answer 22

coronaviridae

Question 23

What are the characteristics of FIP?

Answer 23

RNA, enveloped

Question 24

Which virus does FIP mutate from and where?

Answer 24

FIP mutates from feline enteric coronavirus WITHIN THE HOST

Question 25

What do antibodies to FIP mean?

Answer 25

not necessarily FIP will develop

Question 26

What do both forms of FIP show clinically?

Answer 26

hyperglobulinemia

Question 27

What are some of the other symptoms of FIP?

Answer 27

jaundice, diarrhea

Question 28

What are symptoms exclusive of the non-effusive form of FIP?

Answer 28

anterior uveitis or neurological signs

Question 29

What cells does FeCOV multiply in? | FIP?

Answer 29

FeCOV - enterocytes | FIP - macrophages

Question 30

What causes the vascular damage and leakage of fluid in FIP?

Answer 30

immune complexes and complement activation

Question 31

Is humoral immunity protective in FIP?

Answer 31

NO, may be detrimental

Question 32

What is the gross appearance of FIP?

Answer 32

multiple grayish noodules in abdomen, lungs

Question 33

What are the microscopic appearances of FIP?

Answer 33

acute immune mediated perivascular necrosis that progresses to chronic pyogranulomatous lesion

Question 34

What is characteristic of FIP fluid?

Answer 34

high protein, low cellularity, no bacteria

Question 35

What happens because of the complement depletion in chronic FIP?

Answer 35

immunosuppression

Question 36

How is FIP diagnosed?

Answer 36

no definitive test, combo of CS, PE, fluid

Question 37

What does the rivalta test for and which one would lead to FIP suspicion?

Answer 37

differentiates between transudates and exudates | if exudate --> maybe FIP

Question 38

What is characteristic of FIP fluid?

Answer 38

pyogranulomatous exudate

Question 39

What can antibody ELISA help with in FIP?

Answer 39

shows coronavirus antibodies - if negative, less chance for FIP

Question 40

What are the characteristics of feline panleukopenia virus?

Answer 40

parvoviridae | DNA, naked

Question 41

Where does feline panleukopenia virus replicate?

Answer 41

dividing cells, intranuclear inclusion bodies

Question 42

What kind of environment can feline panelukopenia resist?

Answer 42

60 C for 1 hr and pH 3 to 9

Question 43

What kind of disease does feline panleukopenia cause?

Answer 43

hypoplasia, enteritis, panleukopenia

Question 44

What is another old name for feline panleukopenia virus?

Answer 44

feline distemper

Question 45

What happens during neonatal panleukopenia disease? | all ages?

Answer 45

neonatal - selective cerebellar destruction | All ages - leukopenia and enteritis

Question 46

What happens if kittens are infected in the last 2 weeks of pregnancy or the first 2 weeks of life?

Answer 46

permanently ataxic

Question 47

What are the diagnostics of feline panleukopenia?

Answer 47

panleukopenia antigen capture ELISA in clinic - urgency immunofluoresence

Question 48

How is feline panleukopenia virus transmitted?

Answer 48

direct contact or via fomites (fleas and humans - mechanical)

Question 49

How long do recovered cats from feline panleukopenia shed the virus?

Answer 49

several months (different from canine parvo)

Question 50

What are the vaccines available for feline panleukopenia virus?

Answer 50

attenuated | inactivated - pregnant or kittens

Question 51

How can feline panleukopenia virus be disinfected?

Answer 51

1:32 dilution of sodium hypochlorite

Question 52

Feline herpes causes what disease?

Answer 52

rhinotracheatis

Question 53

What are the characteristics of feline herpes?

Answer 53

DNA, enveloped, intranuclear inclusion bodies

Question 54

What are the clinical signs of feline herpes?

Answer 54

respiratory signs, ulcers in mouth, keratitis

Question 55

What age of cats only have mild or subclinical infection of herpes?

Answer 55

greater than 6 months

Question 56

What my happen in herpes infections in susceptible kittens?

Answer 56

bronchopneumonia - fatal

Question 57

What is a good diagnosis of herpes virus in cats?

Answer 57

responds to L-lysine treatment

Question 58

Is there a vaccine for feline herpes?

Answer 58

yes, does not protect but lessens disease

Question 59

What are the characteristics of the calicivirus (feline)?

Answer 59

RNA, naked

Question 60

How is feline calicivirus transmitted?

Answer 60

aerosol and fomites

Question 61

What are the clinical signs of feline calicivirus?

Answer 61

conjuctivitis, respiratory, ulcers more extensive than herpes, NO corneal ulcers

Question 62

What is the mortalitiy in young kittens with feline calicivirus?

Answer 62

30% because of pulmonary eddema and interstital pneuomonia

Question 63

How can you differentiated between calicivirus and herpes virus?

Answer 63

herpes - enveloped, lipiid solvent test herpes - intranuclear inclusion bodies herpes - responds to L-lysine

Question 65

How do cats shed calicivirus?

Answer 65

continually from oropharynx

Question 66

What 2 cat viruses do not have vaccines?

Answer 66

FIV and rotavirus

Question 67

What are the 4 feline systemic viruses?

Answer 67

FIV FeLV FIP Feline panleukopenia - (also repro and neonatal)

Question 68

What are the 2 feline respiratory viruses?

Answer 68

Feline calicivirus | feline rhinotracheitis

Question 69

What are the 3 naked feline viruses?

Answer 69

Panleukopenia (parvo) Calicivirus Rotavirus

Question 70

What are the 2 feline DNA viruses?

Answer 70

panleukopenia (parvo) | herpes (rhinotracheaitis)