Female Anatomical Abnormalities Flashcards Preview

Reproductive > Female Anatomical Abnormalities > Flashcards

Flashcards in Female Anatomical Abnormalities Deck (31):
1

Pelvic organs are vascularized by what?

Internal Illiac Artery (anterior branch)

2

Male sex organs come from which duct?

Wolfian duct....also known as the Mesonephric duct

3

Female sex organs come from which duct

Mullerian....also known as the Paramesonephric duct

4

Canalization of the female sex organs (vagina, uterus) goes caudal to cranial

ok

5

Canalization is complete at what point in fetal development?

20 weeks

6

What makes the Wolfian duct develop instead of the Mullerian?

Androgens....testosterone and DHT (two main hormones). Females experience much less androgen formation

7

Know this. Females don't have hormones that make the wolfian ducts disappear, its just the absence of Androgens. Males do have anti-mullerian hormone produced by the sertoli cells. Called AMH.

ok. So if a gonad doesn't produce androgen, external genitalia appear female by default.

8

Are Mullerian anomalies genetic?

No. You will not see any mutations on Karyotype. However, it does tend to run in families.

9

Know the Mullerian abnormalities slide

ok

10

Vaginal agenesis

no vagina

11

cervical agenesis

no cervix

12

Fundal agenesis

no uterus pretty much

13

Tubal agenesis

No tubes

14

Unicornuate uterus =

uterus formed by only one of the mullerian ducts

15

Didelphus

Pretty much the two mullerian ducts don't fuse. You end up with two separate cervices, two separate vaginas in many cases.

16

Bicornuate uterus

the outer contour of the uterus is the same shape as the inner contour. Basically the two ducts don't fuse properly and instead of having one large uterine cavity you have two smaller cavities

17

Septate uterus

Looks similar to bicornuate except that the outer contour of the uterus is completel normal. Inner contour has a septum

18

Know the difference between a septate and arcuate uterus

ok

19

DES drug related uterine anomaly.

know

20

What do you call the division point between the upper 2/3 of vagina ( Mullerian duct) and lower 1/3 of vagina (UG sinus)

Hyman ring

21

What gene on the Y chromosome produces testis determining factor?

SRY gene

22

SRY gene produces what

testis determining factor

23

What produces mullerian inhibiting factor

sertoli cells

24

What secretes androgens to encourage the development of the mesonephric (wolfian) ducts

Leydig cells

25

Mullerian duct abnormalities tend to result in what?

anatomical defects that present as amenorrhea despite the fully developed secondary sex organs

26

Mesonephric duct (wolfian) forms what structures in particular?

SEED, Seminal vesicles, Epididymis, Ejaculatory Duct, Ductus Deferens

27

MRKH Syndrome

Complete ageneisis of sexual organs that derive from mullerian ducts. The woman will have ovaries, but she will not have tubes, uterius, cervix, or upper 2/3 of vagina. Rectum is totally attached to posteror bladder

28

Androgen insensitivity?

AI--- male karyotype but they had no sensitivity to androgen so they default produced female genitalia. They do have testis however which means they have sertoli cells and leydig cells. Sertoli cells make MIF so the mullerian ducts don't develop. They only have external female genitalia. Really complicated huh

29

Major consequence of Bicornuate uterus

preterm delivery

30

Major consequence of Septate uterus

infertility, pregnancy loss

31

Uterine myoma

fibrous balls that can mimic septum