Female - Cervix

Question 1

Pre-malignant lesions of cervix ?

Answer 1

1.dysplasia and carcinoma in situ
2.invasive carcinoma

Question 2

Carcinoma type of cervix ?

Answer 2

SCC
adenocarcinoma
adenosquamous Ca
small cell nueroendocrine ca

Question 3

which one - beshi - in cervical carcinoma ?

Answer 3

SCC

Question 4

Dysplasia type ?

Answer 4

CIN-I
CIN-II
CIN-III
Cinsitu

Question 5

CIN full form ?

Answer 5

cervical intra-epithelial neoplasia

Question 6

CIN category?

Answer 6

CIN-1 mild = <1/3
CIN-2 moderate = <2/3 >1/3
CIN-3 severe dysplasia >2/3

Question 7

SIL full form ?

Answer 7

Squamous intra-epithelial lesion

Question 8

CIN inssitu extent ?

Answer 8

full thickness

Question 9

Low grade SIL ?

Answer 9

CIN-1 -Mild

Question 10

High grade SIL ?

Answer 10

CIN-2+3

263

Question 11

Morphology of CIN ?

Answer 11

-cellular immaturity
-cellular disorganization
-nuclear abnormaalities
-inc mitotic activity

Question 12

high risk SIL which one ?

Answer 12

HGSIL

Question 13

Common virus in SIL ?

Answer 13

HPV-16

Question 14

low risk HPV ?

Answer 14

HPV- 6+11

Question 15

risk factors of carcinoma of cervix ?

Answer 15

early age of first intercourse
multiple sexual partner
early first pregnancy
STD
OCP
Cigarette
early first pregnancy

Question 16

high risk HPV ?

Answer 16

HPV-16+18
31 33 35 39 56 58 59 68

Question 17

Low risk HPV cause ?

Answer 17

genital warts +
laryngeal papilloma

Question 18

genital watrs pathological name ?

Answer 18

condyloma acuminata

Question 19

High risk HPV cause ?

Answer 19

high grade CIN
Invasive cervical carcinoma

Question 20

HPV related protein /

Answer 20

E6
E7

Question 21

Carcinoma in situ feature ?

Answer 21

severe dysplasia
diffuse atypia
progressive atypia

Question 22

E6 pathogenesis ?

Answer 22

E6 = binds with p53 = degrade it = upregulate the expression of telomerase = leads to cellular immortalization

Question 23

E7 pathogenesis ?

Answer 23

E7 binds with hypophosphorylated active form of RB & promote the degradation via proteosome pathway —- inhibit p21 p27 = cyclin dependent kinase inhibitors

267

Question 24

exo/ecto-cervix lining ?

Answer 24

squamous epithelium

Question 25

endocervix lining ?

Answer 25

coloumnar

Question 26

Squamouse metaplasia site ?

Answer 26

transformation zone / squamocolumnar juntion

Question 27

what is transformation zone ?

Answer 27

267

Question 28

how to identify undifferentiated cervical Ca ?

Answer 28

IHC

Question 29

Cause of death in cervical carcinoma ?

Answer 29

renal failure

Question 30

clinical importance of transformation zone ?

Answer 30

zone is susceptible to oncogenic HPV

Question 31

Age of cervical carcinoma ?

Answer 31

45-50

Question 32

gross of cervical carcinoma ?

Answer 32

fungating / exophytic infiltrative ulcerating

Question 33

spread of cervical Ca ?

Answer 33

direct spread distant / blood borne metastasis

Question 34

direct spread site of cervical Ca ?

Answer 34

paracervical soft tissue urinary bladder ureters rectum vagina

Question 35

distant metastasis site of cervical ca ?

Answer 35

liver lung bone bone marrow

Question 36

local extension complications of cervical carcinoma ?

Answer 36

hydronephrosis uremia ureteral obstruction

Question 37

Diagnosis of cervical carcinoma ?

Answer 37

269

Question 38

History of cervical carcinoma ?

Answer 38

-vaginal bleeding -faul smelling vaginal discharge -painful coitus - dyspareunia -pelvic pain -wright loss

Question 39

clinical examination of cervical Ca ?

Answer 39

-cervix- fixed -hard in consistency -bleeds on touch -irregular -friable 269

Question 40

suppose tumi remote area te acho ----- kivabe sekhane Dx korba ?

Answer 40

VIA visual inspection + 5% acetic acid

Question 41

screenign test of cancer ?

Answer 41

PAP test

Question 42

biopsy type ?

Answer 42

colposcopic & core biopsy

Question 43

vaccine dose schedule ?

Answer 43

0-2-6 months

Question 44

HPV vaccine group / age ?

Answer 44

school - 12-18 women - 16-25

Question 45

Which stain against vacccine

Answer 45

6 11 16 1 8

Question 46

screening and early detection of cervical carcinoma ?

Answer 46

VIA + acetic acid pap smear HPV DNA tsting by PCR colposcopy

Question 47

kivabe bhujbo ideal pap smear sample paichi ?

Answer 47

-Transformation zone theke nibo -good cellularity

Question 48

PAP full form ?

Answer 48

papnicolaou method

Question 49

when to collect first smear for pap ?

Answer 49

within 21 years / within 3 years of onset of sexuala ctivity thereeafter every 3 years

Question 50

women after 30 yeras old pap test ?

Answer 50

normal cytology + negative for HPV = screened every 5 years

Question 51

women with + HPV?

Answer 51

normal cytology + positive HPV = cervical cytology every 6-12 months

Question 52

which specimen for cervical carcinoma ?

Answer 52

wooden ayres spatula

Question 53

pap smear er jonno which end of spatula ?

Answer 53

humerus er mathar moto je end

Question 54

which type of cytolopathogy ?

Answer 54

abrasive

Question 54

how to collect smear ?

Answer 54

anti-clockwise 360 degree

Question 55

cell types found in cervix >?

Answer 55

superficial intermediate parabasal basal

Question 56

which cell is not found in pap smear >?

Answer 56

basal

Question 57

fixative for pap smear ?

Answer 57

95% alchohol

Question 58

where the smear is fixed ?

Answer 58

koplins jar

Question 59

SCC % in cancer ?

Answer 59

80%

Question 60

IHC ---- intermediate filaments name ?

Answer 60

keratin desmin vimentin glial filaments neurofilaments

Question 61

vimentin site ?

Answer 61

mesenchymal tumoe

Question 62

desmin site ?

Answer 62

muscle tumor

Question 63

keeratin site >

Answer 63

carcinoma mesothelioma

Question 64

role of HPV in cervical carcinoma ?

Answer 64

266

Question 65

endocervical columnar differentiattrion ------------ ??

Answer 65

glandular intraepithelial lesion ----------- invasive adenocarcinoma

Question 66

what is wooden ayres spatula made of ?

Answer 66

plastic / metalic

Question 67

HPV - E5----microscopic view ?

Answer 67

koilonytic atypia

Question 68

mucous screting epithelium ??

Answer 68

endocervix -- columnar

Question 69

biopsy type of cervix ?

Answer 69

cone