Female GU Pathology III: Ovary and Fallopian Tube Flashcards Preview

Pathology > Female GU Pathology III: Ovary and Fallopian Tube > Flashcards

Flashcards in Female GU Pathology III: Ovary and Fallopian Tube Deck (42):
1

Follicular Cysts

Result from unruptured Graafian follicles or ruptured follicle that immediately seals.

2

Corpus luteum cysts

Result from delayed resolution of a corpus luteum’s central cavity - hemorrhage into a corpus luteum may result in hemorrhagic corpus luteum cyst

3

Polycystic Ovarian Syndrome

Excess secretion of androgens due to increased LH cause anovulation leading to ovarian cysts and enlarged ovaries

4

What is the action of LH?

LH stimulates theca cells to produce androgens

5

What is PCOS associated with?

Increased insulin resistance and T2 diabetes

6

Androgen is converted in adipose tissue to estrone resulting in what long‐term potential complication of PCOS?
A. Cervical squamous cell cancer
B. Uterine endometrioid endometrial cancer
C. Uterine serous papillary endometrial cancer
D. Leiomyosarcoma of uterus

B. Uterine endometrioid endometrial cancer

7

What are some symptoms of PCOS?

- Hirsutism
- Virilism
- Acne

8

How does obesity cause estrogen excess?

Androgens are converted to estrone in the adipose tissue

9

What are seem therapies for PCOS?

- Weight Loss
- Metformin

10

What is the most common ovarian tumor?

Surface Epithelial Tumors

11

What are the 2 types of surface epithelial tumors?

- Serous
- Mucinous

12

- Cyst with thin and smooth surface
- Single layer of lining cells similar to that of fallopian tube mucosa
- No cytologic atypic
- No invasion

Benign Serous Cystadenoma

13

- Papillary structures with destructive stromal invasion
- May have presence of psamomma bodies

Serous Cystadenocarcinoma

14

What is the most common type of surface epithelial tumor?

Serous

15

- Multiple cystic mass filled by sticky, gelatinous fluid
- Lining epithelium single row of uniform mucin-filled columnar cells with basal nuclei.
- Absent or minimal cellular stratification, no or minimal cellular atypia

Mucinous Cystadenoma

16

- Destructive stromal invasion, cytologic atypic and filled by sticky, gelatinous fluid

Mucinous Cystadenocarcinoma

17

What are some risk factors for cystadenocarcinomas?

- Nulliparity
- Family Hx

18

What tumor marker is used to monitor therapy response in cystadenocarcinomas?

CA‐125

19

Borderline Tumors

• Morphology and behavior “in between” benign and malignant
• Limited invasive potential
• Better prognosis than overtly malignant
carcinomas

20

Who are germ cell tumors often seen in?

Most common ovarian cancer in children and adolescent females

21

Teratoma

Tumor of germ cell origin that is differentiated embryonic tissue and is comprised of more than one neoplastic cell type

22

• Comprise 90% of all teratomas
• Derive from all germ layers – Ectoderm, Endoderm, Mesoderm

Benign Mature Teratoma

23

Struma Ovarii

A large amount of ovary is thyroid tissue

24

Malignant Teratoma

VERY rare - only 1% of all teratomas and have some malignant component -> SCC/thyroid carcinoma/melanoma

25

- Uncommon tumor, composed of mature and immature (primitive cells) embryonal type tissues
- Most commonly diagnosed in prepubertal girls, adolescents and young woman
- Rapidly growing tumor with frequent capsular rupture

Immature Teratoma

26

- Ovarian counterpart of the testicular seminoma
- Most common malignant germ cell tumor of ovary
- LDH tumor marker

Dysgerminoma

27

What germ cell tumor is radiosensitive?

Dysgerminoma

28

With what germ cell tumor are Schiller‐Duvall Bodies seen?

Endodermal Sinus Tumor

29

Histology
- Large cells with clear cytoplasm
- Stroma with lymphocytes

Dysgerminoma

30

- Neoplasm attempts to recapitulate placental tissue; trophoblasts and syncystiotrophoblasts without chorionic villi
- hCG tumor marker

Choriocarcinoma

31

What tumor has AFP as a marker?

Endodermal Sinus Tumor

32

What class of ovarian tumors has these features:
• Originate from undifferentiated gonadal mesenchyme
• Any age
• Most benign, low malignant potential
• Hormonally active

Sex‐Cord Stromal Tumors

33

Most common ovarian tumor with estrogen production.

Granulosa Cell Tumor

34

This tumor is associated with androgen production and tends to be virilizing.

Leydig Cell Tumor

35

‐ Fibroblasts (fibroma)
‐ Lipid‐laden theca cells (theca)
- May produce estrogen

Thecoma-Fibroma

36

What tumor is associated with Meigs Syndrome?

Thecoma-Fibroma

37

What are the features of Meigs Syndrome?

‐ Right sided pleural effusions
‐ Ascites
‐ Ovarian mass

38

Call-Exner Bodies

Gland like structures filled with eosinophilic material seen in granulosa cell tumors

39

- Metastatic mucinous tumor to both ovaries
- Most commonly gastric carcinoma origin

Krukenberg Tumor

40

A 60‐year‐old woman presented with diffuse abdominal pain and distension of the abdomen. Evaluation revealed disseminated gelatinous ascites and multifocal peritoneal epithelial implants, secreting copious globules of extracellular mucin. Which of the following should be at the top of the differential diagnosis with respect to underling cause of her condition?

A. Gastric carcinoid; ovarian serous cystadenoma
B. Appendiceal carcinoid; ovarian serous cystadenocarcinoma
C. Appendiceal mucinous cystadenoma; ovarian Brenner tumor
D. Appendiceal mucinous cystadenocarcinoma; ovarian mutinous cystadenocarcinoma
E. Gastric GIST; ovarian mucinous cystadenoma

D. Appendiceal mucinous cystadenocarcinoma; ovarian mutinous cystadenocarcinoma

41

Pseudomyxoma peritonii

Extensive intraperitoneal mucous

42

Acute Salpingitis

Ascending sexually transmitted; most common organisms: Gonococcus and Chlamydia

Decks in Pathology Class (203):