Flashcards in Female Pathology, Ovary and Fallopian Tubes Deck (14):
primary tumors of the fallopian tube are associated with mutations in what gene?
most common mass of the ovary
ovarian surface epithelial neoplasms: what increases risk and what decreases risk?
increased risk: obesity, family history, germline mutation in tumor suppressor genes, nulliparity
reduced risk: high parity, use of oral contraceptives
most common ovarian epithelial tumor
malignant serous tumors of ovary: mutations in what genes are associated with low grade and which for high grade?
low grade: KRAS, BRAF, ERBB2
high grade: p53
histology of ovarian serous cystadenocarcinoma
what type of ovarian tumor, if bilateral, is a metastasis until proven otherwise?
endometrioid tumor in ovary --> mutation of _____ gene
dx: ovarian tumor, histology shows transitional type epithelium
most common ovarian germ cell tumor
benign (mature) cystic teratomas
dx: woman in 50s, abnormal uterine bleeding, breast tenderness, ovarian neoplasm histology shows Call-Exner bodies
granulosa cell tumor
granulosa cell tumor in ovary: histology and lab finding
Call-Exner bodies (granulosa cells arranged haphazardly around collections of eosinophilic fluid, resembling primordial follicles)
lab finding: increased estrogen
90% of malignant ovarian tumors are ______
surface epithelial-stromal cell tumors