Female Pathology, Ovary and Fallopian Tubes Flashcards Preview

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Flashcards in Female Pathology, Ovary and Fallopian Tubes Deck (14):
1

primary tumors of the fallopian tube are associated with mutations in what gene?

BRCA

2

most common mass of the ovary

functional cysts

3

ovarian surface epithelial neoplasms: what increases risk and what decreases risk?

increased risk: obesity, family history, germline mutation in tumor suppressor genes, nulliparity
reduced risk: high parity, use of oral contraceptives

4

most common ovarian epithelial tumor

serous tumors

5

malignant serous tumors of ovary: mutations in what genes are associated with low grade and which for high grade?

low grade: KRAS, BRAF, ERBB2
high grade: p53

6

histology of ovarian serous cystadenocarcinoma

psammoma bodies

7

what type of ovarian tumor, if bilateral, is a metastasis until proven otherwise?

mucinous

8

endometrioid tumor in ovary --> mutation of _____ gene

PTEN

9

dx: ovarian tumor, histology shows transitional type epithelium

Brenner tumor

10

most common ovarian germ cell tumor

benign (mature) cystic teratomas

11

dx: woman in 50s, abnormal uterine bleeding, breast tenderness, ovarian neoplasm histology shows Call-Exner bodies

granulosa cell tumor

12

granulosa cell tumor in ovary: histology and lab finding

Call-Exner bodies (granulosa cells arranged haphazardly around collections of eosinophilic fluid, resembling primordial follicles)
lab finding: increased estrogen

13

90% of malignant ovarian tumors are ______

surface epithelial-stromal cell tumors

14

dx: tumor in ovaries or testes in young children, histology shows Schiller-Duval bodies (resemble glomeruli), increased AFP

yolk sac tumor (aggressive)