Female Pathology - Pathoma Flashcards Preview

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Flashcards in Female Pathology - Pathoma Deck (181)
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1

What is this? How can you tell?

Proliferative Endometrium - Mitosis

2

What is this? How can you tell?

Secretory endometrium - tortuous secretory glands + pseduodecidualized stroma

3

What is it? What can cause this?

Endometritis - Inflammation (acute/chronic) - plasma cells in stroma

PIC, retained POC, IUD

 

4

What is this? What might it lead to?

Type 2 Endometrial Carcinoma - Endometrial intraepithelial carcinoma 

Serous Endometrial carcinoma

5

What is this? Who gets it? What is the prognosis?

Type 2 Endometrial Carcinoma - Serous Carcinoma

Older women

Bad - very aggressive

6

Is this a normal fallopian tube?

No - Chronic Salpingitis

7

Label the cysts

A: Follicular cyst

B: Luteal cyst

C: Inclusion cyst

D: Hemorrhagic

8

Which side is normal and which is ductal hyperplasia? 

Left is normal

Right is ductal hyperplasia

9

What is this?

Enlarged lobule, circumscribe edge

Preserved background lobular architecture

Compressed and distorted acini

Dense stroma, calcifications

10

What is this?

Complex sclerosing lesion

(Radial Scar)

11

This lesion presents with nipple discharge, biopsy obtained from the central breast. What is it?

Papilloma

Branching fibrovascular cores w/i duct

Epithelial hyperplasia

12

What are the two types of warty neoplasms of vulvar skin?

1. HPV types 6 & 11 - condyloma acuminatum

2. Secondary syphilis - condyloma latum - less common

13

HPV-associated condyloma are characterized by _____________.

Koilocytes

14

Condylomas _______ progress to carcinoma.

Rarely

15

Lichen Sclerosis 

Leukoplakia (white patch) with parchment-like vulvar skin 

Thinning of epidermis and fibrosis of dermis

Post-menopausal women

16

Lichen Sclerosis is benign, but associated with a _______________ risk for squamous cell CA

Slightly increased

17

Lichen simplex chronicus

Hyperplasia of vulvar squamous epithelium 

Leukoplakia + thick leather-like vulvar skin 

*due to scratching*

No CA risk

18

Where are bartholin cysts located?

Unilateral, lower vestibule adjacent to vaginal canal

19

Vulvar CA presents as _____________ - biopsy may be required.

Leukoplakia

20

What are the two etiologies of Vulvar CA?

1. HPV related: HPV 16 & 18 - from VIN (vulvar intraepithelial neoplasia)

  • Reprodutive Age

2. Non-HPV related: Long-standing lichen sclerosis

  • Elderly woman > 70

21

Vulvar Intraepithelial Neoplasia

Dysplasia

Koilocytic change, disordered cellular maturation, nuclear atypia, and inc. mitotic activity

22

Extramammary Paget Disease

Malignant epithelial cell in epidermis of vulva

23

How does Extramammary Paget Disease present?

Erythematous, pruritic, ulcerated skin

Represents CA in situ

No underlying CA (vs. Pagets of nipple)

 

24

How do you distinguish Extramammary Paget's disease from melanoma of the vulva?

Paget Cells: PAS⊕, keratin⊕, and S100⊖

Melanoma: PAS⊖, keratin⊖, and S100⊕

25

PAS⊕ indicates what

Mucus! 

Carcinoma - epithelial

26

The lower 1/3 of the vagina is derived from ___________.

The upper 2/3 of the vagina is derived from ___________.

Lower = UG sinus 

Upper = Mullerian duct

27

The UG sinus epithelial cells are originally _____________, while the Mullerian duct epithelial cells were originally _______________. What happens if the columnar cells persist?

Stratified squamous 

Columnar epithelium

Adenosis

28

Adenosis occurs with an increased incidence in females exposed to _________________.

DES in utero

*estrogen-like compound*

29

What is associated with DES-associated vaginal adenosis? How common is this?

Clear Cell AdenoCA

rare 

30

Malignant mesenchymal proliferation of immature sk. muscle presenting w/ bleeding and a grape-like mass protruding from vagina/penis of a child.

Embryonal Rhabdoyosarcoma