Female Sex Hormones Flashcards Preview

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Flashcards in Female Sex Hormones Deck (25):
1

During the menstrual cycle, estrogen is made by the __ during the first 14 days then by the __ __ for the last half

follicle; corpus luteum

2

During pregnancy estrogen is made by the

fetal placental unit

3

Female sex hormones are derived from ___ and are converted by ___

testosterone; aromatase

4

Estrogen is needed for both female sexual maturation and ____ closing

epiphyseal

5

Estrogen is vaso___ and increases blood ___ and is cardio___

dilatory; coagulation; protective

6

In the liver, estrogen increases production of ___ and __

leptin; globulin

7

Estrogen promotes the apoptosis of ____ (bone)

osteoclasts

8

Progesterone is produced by the ___ in the non-pregnant state and ___ in the pregnant state

corpus luteum; placenta

9

Progesterone renders the uterus refractory to

oxytocin

10

RU-486 is a classic ___ type _antagonist

progesterone type II

11

Estrogens are given in girls with ____ __ to preserve bone growth

primary hypogonadism

12

Estrogen is used on a __ __ basis for menopause symptoms due to the risk of MI and uterine cancer

short term

13

___ suppresses estrogen dependent breast cancer but is an agonist in the ___ so it may cause cancer

Tamoxifen; uterus

14

Raloxifene suppresses growth in both the __ and the __

breast; uterus

15

___ inhibitors are used in estrogen receptor positive breast cancers

Aromatase

16

___ is responsible for genital and areolar pigmentation

estrogen

17

Estrogen is responsible for __ redistrubtion

fat

18

Estrogen increases these two blood lipids

HDL, triglycerides

19

Estrogen is higher in the __ phase of the cycle and progesterone is higher in the ___ phase

follicular; luteal

20

Type I antagonists act how?

Binding to steroid receptor and blocking its interaction with the GRE/HRE

21

Type II antagonists act by recruiting ___ after binding to ___

co-repressors; HRE/GRE

22

EPT reduces the risk of __ cancer

colon

23

Estrogen therapy alone increases the risk of __ and __ cancer

endometrium; breast

24

SERMs cause the ERE to recruit either __ or __ depending on the confirmation of the tissue which makes it a type __ agonist

co-repressors; co-agonists; III; IV

25

Tamoxifen and Raloxifene are both tumor___

tumoristatic