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Flashcards in Fenger 2 Deck (35):
1

Replication in cytoplasm. Get envelope by budding through membranes of golgi apparatus

Bunyaviridae

2

Transmitted by mosquitos and other ticks

bunyavirus

3

_____ serotypes of bunyaviridae and ______ can cause encephalitis in humans

10
1

4

______ serogroup of bunyaviridae can cause encephalitis in humans

California

5

Found mainly in upper Mississippi and Ohio River valleys. Mosquito vector. Peak July-Sept

California encephalitis virus

6

Onset may be mild
or
abrupt onset bifrontal headache, fever, vomiting, sometimes aseptic meningitis. Systemic and meningeal signs abate gradually within 1 week.

California encephalitis virus

7

LaCrosse encephalitis is member of _____ serogroup

California

8

Certain members cause only a febrile illness in humans, where others cause Crimean-Congo hemorrhagic fever. Transmitted by ________, but blood and secretions of animals and humans are also infectious

Orthobunyavirus. Bunyamwera serogroup
ticks

9

Phlebotomus fever group is transmitted by

sand flies

10

Headache, fever, myalgia, photophobia, neck and back stiffness, papules over body surface
Total recovery w/ immunity for 2 years

Phlebotomus fever group

11

Transmitted by and can infect sheep and other domestic animals which can be transmitted to humans. Saddleback fever, acute onset, GI probs, arthralgia, sometimes hemorrhagic fever.
Recovery usually complete
Vaccine available

Rift valley fever virus

12

Acquired from urine and excretions of rodents. First seen in military personnel in Korea with complications of renal syndrome

Korean hemorrhagic fever virus
Hantavirus

13

Seen in American southwest mainly among native americans. Exposure form aerosols that originate from mouse feces. Infection often leads to pulmonary syndrome.
Higher incidence associated with more rainfall in southwest, which provides better habitat and increased #'s of rodents.

Hantavirus pulmonary syndrome

14

Two cases reported in Randolph county, WV

Hantavirus pulmonary syndrome

15

__________ has efficacy in treating hantavirus pulmonary syndrome if given early in course of infection

ribavirin

16

Could be aerosolized and disseminated by terrorists

hantavirus

17

Wide range of sizes. Helical nucleocapsid surrounded by envelope with dense lipid bilayer. Core particles resemble ribosomes. -RNA consists of multiple segments that appear to be circular. Replicate in cytoplasm using viral RNA pol housed within virus particle

Arenaviridae

18

Arenaviruses are divided into ________ serogroups

2
Old world complex
new world complex

19

Lymphocytic choriomeningitis virus and lassa virus

old world viruses

20

tacaribe virus complex including junin and machupo viruses

new world viruses

21

Arenaviruses hosts are restricted to ______

rodents

22

Infects humans at frequency of 5%, except for those in close contact w/ rodents such as lab workers. Outbreaks reported in ppl who buy hamsters. Urine and feces spread virus. Found in USA as result of house mice infections

Lymphocytic choriomeningitis virus

23

Usually mild with flue like symptoms or infrequently aseptic meningitis.
Fatal disease reported in organ transplant recipients

Lymphocytic choriomeningitis virus

24

Infection of pregnant women during 1st and 2nd trimester can be vertically transmitted to fetus causing severe disease of fetus

Lymphocytic choriomeningitis virus

25

Severe disease could result from immune complex formation

Lymphocytic choriomeningitis virus

26

Causes severe febrile illness in humans. 20% mortality. Infection involves many organs.
Seen mostly in Africa - skin hemorrhages, high hemorrhagic fever, mouth ulcers, severe muscle ache

Lassa fever

27

Spreads from human to human and rodent to human. Rats in Africa chronically infected throughout life and shed high levels of virus into urine

lassa fever

28

Group of viruses causing hemorrhagic fever in Argentina and bolivia

Tacaribe complex

29

Junin is cause in

argentina

30

Machupo is cause in

bolivia

31

Hemorrhagic fevers often result. Mosquitos and mites may transmit virus, but rodent urine and feces are main route.

Tacaribe complex

32

Hemorrhagic fever w/ petechiae, bleeding in GI tract, uterus, nasal cavity, and GU tract

Tacaribe complex

33

___ new world arenaviruses are recognized

15

34

Helical nucleocapsid + envelope with glycoprotein spikes.
-ssRNA in 3 segments (small, medium, and large)
Carries viral RNA pol within viral particle itself
Can undergo reassortment of RNA segments during mixed infections with different strains

Bunyaviridae

35

Hemorrhagic fever viruses could be used for terrorism by raising large populations of infected _______

mosquitos