FINAL

Question 1

Type 1 fiber

Answer 1

-active at low PH
-MHC1
-slow oxidative

Question 2

Type IIa fiber

Answer 2

-active at high pH
-MHC IIa
-fast oxidative/glycolytic

Question 3

Type IIb fiber

Answer 3

-active at high pH and moderately active at pH 4.6
-MHC IIx/d
-fast glycolytic

Question 4

Does respiratory muscle fatigue clinically exist? (2 cases)

Answer 4

1) Burki 1976 - Detection of elevated serum creatine kinase following acute exacerbation of asthma 
CK levels correlated with severity of airway obstruction (FEV1)
2) Cohn 1984 – weaning from mechanical ventilation —> some patients showed shift in power spectrum,
respiratory alternans, and all patients needed mechanical ventilation within 40 mins
o Lacked sensitivity

Question 5

Mechanical ventilation causes decrease in diaphragm force (40%) due to

Answer 5

1. Atrophy via mechanical ventilation