Final Exam Flashcards
What is the purpose of vitamins?
Promote growth and health maintenance
What are the two classes of water soluble vitamins?
B and C
What are the four classes of fat-soluble vitamins?
ADEK
Do we need multivitamins?
Nope- can get everything from a balanced diet
Why is fortification of foods a concern for vitamins?
If too much fortification or consumption of fortified foods, can have vitamin toxicities
Why was 1994 an important year in the vitamin industry?
Supplements became unregulated based on a 1994 bill– allowed supplements to have whatever they wanted in them; concern for toxicities; no validity required for so-called “natural” sources
Why are vitamin supplements insufficient for vitamin intake?
Don’t supply phytonutrients like real food does, and doesn’t provide any real-food-related health benefits from a varied diet
What needs to happen in order for the body to use vitamins?
Need to be absorbed – won’t create toxicity if not absorbed
What does it mean to be a fat soluble vitamin?
Needs to be ingested with fat and transported in chylomicrons
What does it mean to be a water soluble vitamin?
May require transport molecules or something else specific in the GI tract, but can be easily transported in aqueous solutions
What chemical group do many (all?) B vitamins function as?
coenzymes – vitamin combines with a chemical group to form a functional coenzyme, which combines with another subunit to create the active enzyme; can be separated and reused after participating in a reaction
What does it mean for a B vitamin to become activated?
Has combined with a chemical group to create a functional enzyme subunit – but still must combine with another enzymatic subunit to become a fully functional enzyme
What is the general function of B vitamins?
Help with energy release in metabolism; do not supply energy themselves, but can make the metabolic process more productive
Why is frozen food so high in phytonutrients?
Because can have it on the plant longer – freeze right after it gets ripe, not before
Is organic a real thing?
Not really – many organic farms are right next to non-organic farms, so pesticides and chemicals may travel due to soil, air, water, etc.
What are the seven B vitamins?
Thiamin, riboflavin, niacin, B6, biotin, B12, folate
What is thiamin?
First B vitamin identified: “B1” – helps with energy production and carb metabolism
Name thiamin’s function.
Assists in energy production, helps with carb metabolism (conversion of pyruvate to acetyl-coA); nervous system health (because NS uses a lot of energy)
What is thiamin deficiency?
Beri-beri (“i can’t i can’t) – nervous system failure; also associated with Wernicke-Korsakoff syndrome in alcoholics
What are some sources of thiamin?
pork, lentils, bread and spaghetti from fortification
What is riboflavin?
B vitamin found in milk, pork
How does riboflavin respond to light/heat?
destroyed by light/heat – reason for opaque milk containers
What two electron carriers is riboflavin used as a coenzyme for?
FAD and FMN (can remember because of names: “flavin etc. etc.”
What part of metabolism is riboflavin important for?
electron transport chain – used in FAD and FMn electron carriers
What is riboflavin deficiency?
ariboflavinosis (rare in US) – inflammation in lips, mouth, tongue
What is niacin?
B vitamin synthesized from AA Trp
Where do you get niacin from?
Meat sources – can be synthesized from Trp
How does niacin function as a coenzyme?
NAD and NADP – “nicotinamide etc. etc.” for energy release in metabolism
Where in metabolism is niacin important?
glycolysis, TCA, ETC – used in NAD and NADP
What ia niacin deficiency?
pellagra: four Ds (dermatitis, diarrhea, dementia, death)
What are the four Ds of pellagra?
Dermatitis, diarrhea, dementia, death (because NAD and NADP are so necessary throughout all of metabolism)
How can you avoid pellagra on mostly-corn diets?
Treat the corn with an alkaline substance
What is niacin toxicity?
high blood pressure, cardiac arrhythmia, elevated blood sugar levels, impaired liver function (but DOES lower VLDL….)
What is biotin?
B vitamin: coenzyme in energy metabolism
Where can we find biotin?
liver, egg yolks, yogurt, nuts
What is vitamin 6?
pyridoxine (includespyridoxal, pyridoxine, and pyridoxamine) – help with pyridoxal phosphate coenzyme
Where is pyridoxal phosphate mostly used in the body?
Coenzyme for transamination and deamination (AA metabolism)k
What is Vitamin B6 deficiency?
related to anemia due to impaired hemoglobin and NT issues; but pretty difficult to become deficient
What is B6 toxicity?
irreversible nerve damage – DO NOT take B6 supplements
What is folate?
Part of THFA: tetrahydrofolic acid; involved in DNA synthesis
Where is folate used in the body?
DNA synthesis and metabolism of some AAs
Due to its function, what times during life is folate important?
Growth! Needed for DNA replication, etc. – very important in natal and childhood care
What happens with low folate?
increased risk of heart disease due to increase in homocysteine (oxidation risk)
What are some issues with folate supplementation?
can mask a B12 deficiency!!
What food sources are high in folate?
Fol-iage sources! Leafy greens, etc.
What is folate deficiency?
abnormal RBC, megaloblastic RBCs (because replicating cells an’t divide)
How does chemotherapy affect folate?
Blocks it – to prevent replication; this is why chemo is particularly bad for young children who are growing
What is Vitamin B12?
required for folate to function; releases it from THFA; maintains myelin on nerves
What is B12 deficiency?
pernicious anemia – immature RBCs; can cure if there’s sufficient folate, but need to be very careful when treating so as not to ignore B12 deficiency
Why must we be careful when treating B12 or folate deficiencies?
Excess folate can mask B12 deficiency – so if you just supply folate, you run the risk of perpetuating the B12 deficiency which can cause irreversible nerve damage; better to fix B12 just in case to prevent nerve damage and see if folate gets better as a consequences
What should you do if someone presents with pernicious anemia?
Test for folate AND B12 deficiency – don’t want to risk irreversible nerve damage from B12 deficiency by only fixing folate
Is B12 deficiency usually a dietary concern?
No – there are a lot of steps for absorption, so if you’re going to fix it, need to administer by injection
Is B12 related to weight loss?
NOPE! that’s a doctor scam – can’t charge if only giving weight loss advice, so just gave a B12 shot to be able to charge insurance
What is Vitamin C?
Ascorbic acid – antioxidant to help with immune system
What destroys Vitamin C?
oxygen, light, heat, contact with copper/iron cookware
What are the functions of Vitamin C?
antioxidant, helps maintain immune system, production of collagen, aids in iron absorption but only from plant sources
What it Vitamin C’s role in collagen synthesis?
Helps crosslinks for between collagen strands for healthy tissues
What is Vitamin C deficiency?
Scurvy! No crosslinks in collagen so get bleeding gums, etc.
How do antioxidants work?
free radicals have an unpaired electron that can damage lipoproteins, membranes, etc. – but Vitamin C can donate an electron to neutralize the free radical and minimize oxidation of other important molecules
What is required for absorption of fat soluble vitamins?
Lipid, bile, chylomicrons, and lymphatic system
Why are fat soluble vitamins more flexible in intake consistency than water soluble?
Stored in fat, so can keep stores of the vitamin for a while even if not ingesting it
Why are fat soluble vitamins a higher risk for toxicity?
Harder to excrete because they’re stored in fat
What does it mean that Vitamin A is preformed vs precursor?
Preformed is what we mean when we say Vitamin A (retinoids) – precursor is carotenoids which can be made into Vitamin A
Where are retinoids found?
Only in animal products
Where are carotenoids found?
Plant foods: reds, yellows, oranges
what are the functions of preformed vitamin A (retinoids)?
key role in night vision, help with cell differentiation, growth regulation (retinoic acid helps with acne)
What are the functions of the precursor vitamin A (carotenoids)?
need fat to be absorbed; yellows decrease risk of macular degeneration; overall decrease cancer risk
What happens with Vitamin A deficiency?
night blindness, long term permanent blindness, xeropthathalmia (lack of mucous synthesis in eye, becomes keratinized)
what happens with Vitamin A toxicity?
hip fractures in postmenopausal women; severe birth defects with use of RetinA or Accutane for skin conditions
What is vitamin D?
Sunshine vitamin: produced in skin after exposure to UV light; acts like a hormone in the body
What is cholecalciferol?
Active Vitamin D
What are the functions of Vitamin D?
Bone health, works with PTH at kidney level to retain more calcium; increases bone breakdown to release calcium into the blood
Can you suffer from Vitamin D toxicity?
No probably not
What is vitamin D deficiency?
prevents proper bone mineralization; abnormalities in bone structure; dietary calcium can’t be absorbed efficiently;
What does Vitamin D deficiency called in children vs adults?
Children: rickets (weak bones, bowed legs); Adults osteomalacia (bone and muscle pain, poor quality bone)
What does the book say happens due to Vitamin D toxicity?
Depositing of calcium in blood vessels and kidneys, cardiovascular damage, and possibly death
What is Vitamin E?
Eight forms, has antioxidant purposes
What is tocopherol?
four forms of Vitamin E (?)
What are the properties of alpha-tocopherol?
antioxidant properties
What does your intake need to include to use Vitamin E?
vegetable oils – especially EVOO
What does Vitamin E do in the body?
keeps LDL from being oxidized
How does Vitamin C interact with E?
C keeps E healthy
What is the function of Vitamin K?
coagulation
What are the names of Vitamin K found in plant vs animal sources?
phylloquinone in plants, menaquinone in animals
What is coumadin/warfarin?
anticoagulation medicine - interferes with Vitamin K activity
What percent of blood is water?
90%
What are some functions of water?
Tears to wash away dirt, synovial fluid to jubricate joints, saliva to help with chewing and swallowing, spinal fluid to protect against shock, body temperature regulation
When you’re thirsty, does that mean you’ve just gotten dehydrated?
No - thirst kicks in way after you become dehydrated
What are electrolytes?
Deficiency is related to fluid loss and medications
When can you get potassium toxicity?
supplements or renal disease
When can you get sodium toxicity?
very rarely
What is wrong with hypertension?
increased pressure against arterial wall – cardiovascular risk
What are risk factors for HTN?
genetics, age, diet, obesity, ethnicity, diabetes, smoking, stress, alcohol, limited physical activity
What is a dietary solution to HTN?
restrict sodium
What is the DASH diet?
to reduce sodium – controlled diet and food is provided; fruits and veggies (most contain potassium which is a major intracellular electrolte)
What are minerals?
Needed by body in small amounts for health and maintenance
What is the important thing about mineral intake?
Need correct proportion of intake of different minerals; bioavailability!!
What is bioavailability?
amount of mineral in food that is absorbed and available to body