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Flashcards in First Midterm Deck (31):
1

Types of insulin replacements

Lispro, natural, NPH, Glargine

2

Metformin

Activates AMP Kinase, which is involved in metabolism, and increases insulin sensitivity. gastroINT issues possible

3

Sulfonurea

insulin secretogogue

4

Glyburide

type of sulfonurea

5

Meglitinide

Insulin secretogogue

6

Rapaglinide

Type of meglitinide

7

Sitagliptin

DPP4 inhibitor

8

Exenatide

GLP-1 receptor agonist

9

Dapagliflozin

gliflozin, blocks SGLT2

10

Canaglifozin

Gliflozin, blocks SGLT2

11

Rosiglitazone

Type of Sulfonurea (Avandia). PPAR agonist

12

Pioglitazone

Type of Sulfonurea (Actos). PPAR agonist

13

Heparin

active ingredient in st johns wort

14

Prednisone

High dose anti inflam (for Mary Thomson)

15

leuprorelin

GnRH Analog

16

Androderm

Testosterone patch

17

Striant

Testosterone on gums

18

Testosterone Enanthate

Testosterone ester derivitive, added by intramuscular injection

19

Degarelix

GnRH antagonist (also no flare up)

20

Ketoconazole

Inhibits testosterone biosynthesis. also works to inhibit estrogen synthesis, bcc not testosterone means no estrogen

21

Spironolactone

testosterone biosynthesis

22

Finasteride

5 alpha reductase

23

Flutamide

competitive antagonist of Testosterone receptor

24

Cyproterone

antagonist of Testosterone receptor

25

Tamoxifen

Estrogen receptor antagonist, works at "the tam tams" hehehe. Um. also is an agonist at the endometrium tissue which is bad.

26

raloxifene

Is an estrogen receptor agonist, works at the bone. is used instead of Tamoxifen because it also has antagonistic activity at the breasts(RELAXING FIEND, LAZY BONES!)

27

clomifene

ER antagonist. works at the pituitary and hypothalamus. Prevents estrogen negative feedback, and is used to help with infertility.

28

Fulvestrant

ER Antagonist. Doesnt allow estrogen receptor to dimerize.

29

Danazole

Binds to various sex hormone receptors partially, can cause masculinizing effects. Works so that the precursor, Androstenedione, doesnt get made. used to treat endometriosis.. P450 C17 inhibitor. used to treat endometriosis.

30

Anastrozole

Inhibits aromatase

31

proxyfan

the first protean ligand