First Trimester complications Flashcards Preview

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Flashcards in First Trimester complications Deck (23):
1

Risk of malignancy GTN in complete molar pregnancy

 

in partial

complete: 2% risk of choriocarcinoma, 

15-20% invasive moles

partial: rare assoc with choriocarcinoma, >2% invasive moles

2

 

embryonic pole visible on ultrasoun

no cardiac activity

 

anembryonic demise - gestation sac without corresponding embryo indentified on ultrasound

missed abortion with embryonic demise =

 

with anembryoic demise =

2

morphology+ appearance complete molar pregnancy

 

genotype

partial mole contains fetal tissue

arises from fertilizzatio of haploid ovum by two sperm or single sperm that then duplicates

Triploid (69,XXX) 69 XYY 69 XXY

3

implantation complete by day 

9-10

3

missed abortion with embryonic demise =

 

with anembryoic demise =

embryonic polel visible on ultrasoun

no cardiac activity

 

anembryonic demise - gestation sac without corresponding embryo indentified on ultrasound

3

risk factors of ectopic pregnancy

PID

gonorrhea or chlamydia

previous tubal ligation or pregnancy

assited reproductive technologies

smoking

pregnancy with IUD

4

majority of tubal prgnancies located in 

ampullary region

5

morphology+ appearance complete molar pregnancy

 

genotype

trophoblastic proliferation and hrydropic grape like chrionic villi

snowstorm appearance on ultra sound

results from fertilization o fenucleate egg

paternally derived diploid genotype (46XX, some 46XY)

no fetal structures develope

6

partial passage of products of conception

open os

variable bleeding

nonviable pregnancy

incomplete abortion

6

finding consistent with all forms of gestational trophoblastic disease

high hCG

8

can visual pregnancy with ultrasound at hCG levels of ___

this is called the ____

1500-2000

discriminatory zone of hCG

9

recurrent pregnancy loss =

3 or more spontaneous losses before 20 weeks

10

incomplete abortion

partial passage of products of conception

open os

variable bleeding

nonviable pregnancy

12

structure and specificity of hCG

alpha subunit identiacal to LH, FSH, TSH

beta unit unique to hCG

13

mechanism methotrexate

 

indications

binds dihydrofolate reductase (conpetitive antagonist)

interferes with DNA synthesis and cell replication

 

ectopic pregnancy, hydatiform molar pregnancy, choriocarcinoma

15

bleeding or cramping with no passage of tissue

closed os

intrauterine pregnancy

heart tones present is age appropriate

threatened abortion = 

15

bleeding

open os

no passage of products of conception

non-viable prengnacy

inevitable abortion = 

16

inevitable abortion = 

bleeding

open os

no passage of products of conception

non-viable prengnacy

17

threatened abortion = 

bleeding or cramping with no passage of tissue

closed os

intrauterine pregnancy

heart tones present is age appropriate

19

peak hCG levels occur at (time)

level?

0 weeks 

100,000mIU/ml

21

complete abortion = 

porducts of conception completely passed

closed os

minmal bleeding

uterus well contracted 

22

benign forms of gestational tropholbalstic disease

 

malingnant forms

hydatiform mole )benign)

persistent or invasive GTD

choriocarcinoma

placental site trophoblastic tumor disease

23

mechanism urine pregnanyc test

MAB specific to beta unit of hCG

detection between 20-100mIU/ml hCG

(hCG at first missed period is 100mIU/mL)