Fiser Chapter 3 BLOOD PRODUCTS Flashcards Preview

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Flashcards in Fiser Chapter 3 BLOOD PRODUCTS Deck (17):
1

Blood products without HIV and hepatitis risk

albumin and serum globulins (heat treated)

2

Diseases donated blood is screened for

HIV, HepB, HepC, HTLV, syphilis, West Nile

3

Who gets CMV-negative blood?

Low birth weight infants, BMT patients, transplant patients

4

Universal donor blood

Type O

5

Hemolysis reactions

Acute hemolysis
Delayed hemolysis
Nonimmune hemolysis

6

After transfusion: back pain, chills, tachycardia, fever, hemoglobinuria

Acute hemolysis: ABO incompatibility, Ab mediated
Can lead to ATN, DIC, shock
Dx: Haptoglobin 5 g/dL, increased unconjugated bilirubin
Tx: Fluids, diuretics, HCO3, pressors, Benadryl
If intubated may present as diffuse bleeding

7

Acute hemolysis transfusion reaction mechanism and treatment

ABO incompatibility
Fluids, diuretics, HCO3, pressors, benadryl

8

Delayed hemolysis mechanism

AB mediated against MINOR antigens
Tx: observe if stable

9

Nonimmune hemolysis mechanism

Squeezed blood...
Tx: fluids and diuretics

10

Transfusion reactions

Hemolysis (acute, delayed, nonimmune)
Febrile nonhemolytic (most common)
Anaphylaxis
Urticaria
TRALI

11

Febrile nonhemolytic transfusion reaction mechanism and treatment

-Recipient Ab attacks donor WBC

-Tx: Discontinue transfusion if previous transfusions or if occurred soon after transfusion begun. Use WBC filters for subsequent transfusions

12

Anaphylaxis transfusion reaction mechanism and treatment

-IgA deficiency: recipient Ab attacks donor IgA

-Tx: fluids, Lasix, pressors, steroids, epinephrine, benadryl

13

Bronchospasm, hypotension, urticaria with transfusion

Anaphylaxis in IgA deficiency

14

Urticaria transfusion reaction mechanism and treatment

-Recipient Ab against donor plasma proteins or IgA

-Tx: Benadryl, supportive

15

TRALI mechanism

Donor Ab to recipient WBC -> clot in pulmonary capillaries

16

Most common bacterial contaminant in blood

GNRs, E coli

Can get Chagas' disease too

17

Most common product with contamination

platelets