Fluoroquinolones

Question 1

Examples:

Answer 1

1. Ciprofloxacin
2. Levofloxacin
3. Delafloxacin
4. Moxifloxacin
5. Gemifloxacin

Question 2

MOA:

Answer 2

1. Inhibiting the synthesis & replication of DNA in bacterial cells

Question 3

Spectrum:

Answer 3

1. Gram-positive cocci
2. Gram-negative rods

Question 4

Indications:

Answer 4

1. Complicated & uncomplicated UTIs
2. Chronic prostatitis
3. Atypical pneumonias - Legionella, Chlamydophila & Mycoplasma
4. AE of COPD

Question 5

S/E:

Answer 5

1. C. dificile colitis
2. Confusion & CNS toxicity
3. Cardiac disturbances - prolonged QT interval
4. Hypoglycemia or hyperglycemia
5. Tendinopathy

Question 6

Contraindications:

Answer 6

1. NOT be used in children