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Flashcards in fong V Deck (19):
1

in the loop of henle, is the transport in the thin segments active or passive?

passive

2

is transport of NaCl in the thick ascending limb active or passive?

active

3

what 2 things inhibit Na+/K+/Cl- cotransporter?

bumetanide and lasix

4

lack of water permeability results in what?

dilution of the luminal fluid

5

what is impaired in Bartter syndrome?

NaCl absorption

6

what drives NaCl uptake in the DT?

Na+ gradient

7

what inhibits the Na+/Cl- cotransporter?

chlorothiazide (diuril)

8

distal tubular Ca2+ absorption is regulated by what?

PTH

9

PTH is released in response to what?

low plasma calcium

10

what types of cells are in the collecting ducts?

-principle cells
-alpha intercalated cells
-beta intercalated cells

11

what cells of the collecting duct absorb Na+ via ENaC?

principle cells

12

ENaC is regulated by what hormone?

aldosterone

13

what blocks Na+ absorption by inhibiting ENaC?

amiloride

14

water permeability of the collecting duct principle cells is modulated by what?

ADH

15

what water channel does ADH work on?

AQP2

16

what happens when the AQP@ and CD ADH-regulated H20 permeability loses it function because of mutation?

NEPHROGENIC diabetus insipidus

17

what are the signs of nephrogenic DI?

-inability to concentrate urine
-massive water diuresis

18

alpha intercalated cells secrete what?

acid (carnivores)

19

beta intercalated cells secrete what?

base (bicarb) (herbivores)