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Flashcards in Friday Groupings/Definitions/Presentations Deck (28):
1

Causes of follicular hyperplasia

RA
toxo
early HIV infection

2

Reactive vs neoplastic follicles

architecture preserved in reactive

3

What causes paracortical hyperplasia?

T-cell mediated responses
ie/mono

4

Sinus histiocytosis definition & cause

increase in number and size of cells in lymphatic sinusoids
in nodes draining carcinoma of the breast

5

List the peripheral B Cell Lymphomas

lymphoplasmacytic lymphoma
splenic and nodal marginal zone lymphomas
extranodal marginal zone lymphoma
mantle cell lymphoma
follicular lymphoma
marginal zone lymphoma
diffuse large b cell lymphoma
burkitt lymphoma

6

List the Peripheral T cell and NK cell lympohoma

unspecified peripheral T cell lymphoma
anaplastic large cell lymphoma
extranodal nk/t-cell lymphoma

7

List the hodgkin lymphoma classical subtypes

nodular sclerosis
mixed cellularity
lymphocyte depletion

8

Other hodgkin lymphoma (non-classical)

lymphocyte predominance

9

Burkitt Lymphoma features

germinal center B cell derived
African/Endemic & sporadic types
aggressive in those with HIV
adolescents or young adults with extranodal masses
EBV associated
aggressive

10

Diffuse large B cell lymphoma features

germinal center B cell derived
usually adults
30% extranodal
aggressive
most common form of NHL
large cell size, diffuse growth pattern

11

Extranodal marginal zone lymphoma features

memory B cell
extranodal sites in adults with chronic inflammatory disease
may remain localized
indolent
may regress if inciting agent is eradicated

12

Follicular lymphoma features

germinal center B cell
older adults
generalized lymphadenopathy + BM involvement
paratrabecular lymphoid aggregates
indolent
incurable

13

Mantle Cell Lymphoma features

naive B cell
older males
20-40% w/PB involvement
disseminated disease
moderately aggressive

14

Peripheral T-cell lymphoma, unspecified, features

helper or cytotoxic T (mature)
older adults
usually lymphadenopathy
sometimes eosinophilia, pruritus, fever, wt loss
aggressive (worse prog than comp agg B cell neoplasms)
pleomorphic mixture of T cells

15

Anaplastic large cell lymphoma features

cytotoxic T cell
children and young adults
lymph node & soft tissue disease
aggressive
"hallmark cells"-large anaplastic cells
very good prognosis

16

Extranodal NK/T-cell lymphoma features

nk cell (common)
cytotoxic t cell (rare)
adults with destructive extranodal (esp nasopharyngeal) masses
usually sinusoidal
aggressive
associated with EBV

17

What does follicular lymphoma transform to most often?

diffuse large B-cell lymphoma

18

Burkitts histology

high mitotic index
starry sky pattern

19

What does burkit's lymphoma almost always fail to express? What does this result in?

BCL2
lack of apoptosis

20

How does endemic burkitt present?

mass involving mandible
abdominal visceral-kidneys, ovaries, adrenals

21

How does sporadic burkitt present?

mass involving the ileocecum and peritoneum

22

Lymphoplasmacytic lymphoma features?

monoclonal IgM, can cause hyperviscosity syndrom known as waldenstroem macroglobulinemia
marrow with infiltrate of lymphocytes, plasma cells and plasmacytoid lympohcytes in varying proportions

23

Mantle cell lymphoma prognosis?

3-4yrs

24

Where are peripheral T and NK cell neoplasms most common?

Asia/Far east

25

Hodgkin Lymphoma features

tumor giant cell-Reed Sternberg Cells (binucleate)
spread in stepwise fashion to anatomically contiguous nodes
Bcell origin

26

What is the most common hodgkin lymphoma?

nodular sclerosis

27

Nodular sclerosis Hodgkin features

cervical, supraclavicular, mediastinal LNs
adolescents/young adults
prognosis excellent
lacunar cell
collagen bands

28

Mixed-Cellularity Hodgkin Lymphoma

most comomn hodgkin in pts older than 50