From golgi to lysosome Flashcards Preview

MCBL > From golgi to lysosome > Flashcards

Flashcards in From golgi to lysosome Deck (14):
1

What is the pH of lysosomes?

4.5-5

2

How is the low pH maintained?

H+ pump (vacuolar H+ pump in membrane)

3

how are digested material transported to the membrane?

H+ gradient (secondary transport)
specific transport proteins

4

What is used to degrade the material in lysosomes?

acidic hydrolases

5

What is the mannose 6-phosphate receptor used for?

it recognizes lysosomal hydrolases tagged with M6P in the TGN

6

What signals for the addition of M6P?

a signal sequence

7

What mediates the addition of of M6P?

N-acetylglucosaamine (GlcNAc) phosphotransferase
GlcNAc phosphoglycosidase

8

Where is the M6P receptor?

shuttles back and forth between membranes

9

What two types of receptors mediate M6P sorting to lysosomes?

CI-M6PR mediates cell surface IGF-II binding through short high affinity peptide sequences in IGF-II
it can also bind M6P moieties and deliver them to the lysosome

10

What is the pathway of hydrolases?

ER-> Golgi-> endosomes ->lysosomes

11

What is the pathway of endocytosis?

early endosomes -> late endosomes -> lysosomes

12

What is the pathway of phagosytosis?

Phagosomes ->lysosomes

13

What is the pathway of autophagy?

autopphagosomes -> lysosomes

14

What does digestion of organelles provide?

energy during starvation

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