Functional bowel disease and IBS Flashcards Preview

GI Year 3 > Functional bowel disease and IBS > Flashcards

Flashcards in Functional bowel disease and IBS Deck (11)
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1
Q

describe functional bowel disease

A

a functional GI disorder with symptoms attributable to the mid or lower GI tract

2
Q

describe IBS

A

recurrent pain associated with abnormal defectation in the absence of structural abnormality - 10-15% affected, and only 10% will consult

3
Q

% of IBS psychiatric

A

50%. Can be brought on for acute stress

4
Q

describe seritonergic response

A

excess release in IBS-D, and deficiency in IBS-C.

5HT antag for D, and ag for C!

5
Q

what controls intestinal motility and secretion

A

the enteric NS. The GI tract contains 95% of the body 5HT, from enterochromafin cells

6
Q

criteria for diagnosis

A

ROME III –> recurrent abdo pain at least 3d/mth in the last 3 months associated with two or more of the following

i) improvement with defecation
ii) onset assoc w/ frequency change
iii) onset assoc w/ form appearance

7
Q

average age of IBS presentaion

A

20-40

8
Q

DDx of diarrhoea

A
  • coeliac
  • lactose
  • thyrotoxicosis
  • microscopic colitis
  • bile acid malabsorption
  • parasitic infection
9
Q

typical IBS course

A

relapse remitting, with exacerbations following stressful life events

10
Q

drugs for persistent diarrhoea

A

amitryptiline and imipramine (TCA)

rifaximin (Abx)

11
Q

drugs for persistent constipation

A

prucalopride (v selective 5HT agonist)

linaclotide (guanylate cyclase C agonist)