gallbladder and bile production Flashcards Preview

GI > gallbladder and bile production > Flashcards

Flashcards in gallbladder and bile production Deck (23):
1

functions of liver

metabolism
synthesis
storage
detox
inactivation
activation
bile production

2

bile flow

hepatocytes -> bile canaliculus ->perilobular ducts -> interlobular ducts -> septal ducts -> lobar ducts -> r/l hepatic duct -> hepatic duct -> common bile duct -> duodenum

3

sinusoids

spaces btwn hepatocytes
filled w/blood
wider than cappilaries, fenestrated
lined w/endothelial cells and kupffer cells

4

space of Disse

stella cells present
plasma sloutes, not blood cells
kupffer cells cleanse blood of bacteria, toxin, paracites, and old RBCs as it passes before returning to circulation

5

bile formation

hepatocytes actively secrete isotonic bile
intrahepatic and extrahepatic ducts secrete bicarb rich fluid into it as well
this can create a liter of hepatic bile/day
half diverted to gallbladder for storage

6

primary bile acids

cholic acid
chenodeoxycholic acid

7

four major components of bile

bile salts
cholesterol and phospholipids
bilirubin
protein and miscellaneous (such as bicarb)

8

functions of bile

fat digestion and absorption
waste product excretion (bilirubin, cholesterol, lipophilic drugs, trace minerals)

9

total bile flow

canalicular flow + ductular flow

10

canalicular flow

independent flow + dependent flow

11

ductular flow

constant

12

choleretics

increase bile secretion
secretin
glucagon
VIP
GRP

13

somatostatin

inhibitory to bile secretion by:
enhancing fluid absorption
inhibits secretion

14

Mucus

secretion by gallbladder epithelial cells protects apical surface of gallbladder epi from toxic effects of bile salts
excessive mucin deleterious can lead to cholesterol cholelthiasis

15

CCK

presence of fatty foods trigger release
causes contraction of gallbladder
causes relaxation of spinchter of oddi

16

acetlycholine

secreted from vagus and intestinal enteric NS
stimulates gallbladder less strongly then CCK

17

circulation of bile

47% returned via active transport through hepatic portal vein from terminal ileum
lose less then 5% of bile salts/day in stool
called enterohepatic circulation of bile salts
47% diffuse through mucosa in early portions of small intestines

18

cholestasis

suppression of bile secretion
3 major negative effects:
-regurgitation of bile components into blood -> jaundice and pruritus
-damages hepatocytes (increase in liver enzymes in blood)
-lipid digestion and absorption impaired

19

cholelithiasis

formation of stones w/in gallbladder or duct system

20

cholecystitis

inflammation of gallbladder

21

cholangitis

inflammation of biliary ducts

22

gallstone causes

-too much water absorption from bile
-too much absorption of bile acids from bile
-too much cholesterol in bile
inflammation of epi

23

contributing factors of chlethiasis

supersaturation
gallbladder hypomotility
crystal nucleation
accretion w/in mucous layer