Gastric Carcinoma Flashcards Preview

Gastrointestinal Conditions > Gastric Carcinoma > Flashcards

Flashcards in Gastric Carcinoma Deck (10):
1

Sex preponderance of gastric carcinoma:

M>F (2:1)

2

Risk factors for gastric Ca:

* Advancing age
* Pernicious anaemia
* Blood group A
* H. pylori
* Atrophic gastritis
* Adenomatous polyps
* Hypogammaglobulinaemia
* Lower SES
* Smoking
* Diet
High nitrate
High salt
Pickling
Low vitamin C
* Nitrosamine exposure

3

Symptoms of gastric Ca:

Often non-specific

* Dyspepsia
* Weight loss
* Vomiting
* Dysphagia
* Fatigue, SOB (IDA)

4

Signs of gastric Ca:

* Epigastric mass
* Hepatomegaly
* Jaundice
* Ascites
* Virchow's node (L. SC fossa)
* Acanthosis nigricans

5

Differential diagnosis of gastric Ca:

* Gastritis
* Oesophagel Ca
* Oesophageal stricture
* Peptic ulcer
* NH-lymphoma (e.g. Gastric MALT)
* Gastroenteritis
* Small bowel malignancy

6

Investigations in gastric Ca:

1. Bloods: FBC, LFTs

2. Urgent OGD: + biopsies

3. CT/MRI TAP: for staging

7

Staging of gastric Ca:

TNM

8

Management of gastric Ca:

Surgical
* Gastrectomy
Total if proximal 1/3
Partial if distal 2/3

May be curative if localised

Medical
Combination chemo
Trastusumab (if HER-2+)

Palliation
Pain/obstruction/haemorrhage

9

Complications of gastric Ca:

* Chemotherapy complications
* Metastatic disease
* GIT obstruction
* GIT haemorrhage
* GIT perforation

10

5 year survival of gastric Ca:

<10%