Flashcards in Gastritis Deck (28):
What is gastritis?
Inflammation of the stomach.
What are the folds of the stomach called?
What can cause acute gastritis?
Irritant chemical injury
This is erosive and can lead to blood loss.
What can cause chronic gastritis?
What causes Autoimmune gastritis?
Production of anti-parietal and anti-intrsinci factor antibodies
(Parietal cells are that produce acid)
(Intrinsic cells produce intrinsic factor)
Macrocytosis - due to B 12 deficiency
What is pernicious anaemia?
Anaemia caused by gastritis
What is macrocytosis?
This is enlargement of the red blood cells through deficiency of B 12
Where does H pylori inhabit?
Inhabits a niche between the epithelial cell surface and mucous barrier
- This causes an acute inflammatory response
What type of bacteria is H Pylori?
Gram Negative curvillinear rod (Look like stick birds)
What does H pylori increase the risk of?
What is the test for H pylori?
Stool antigen test.
C 13 antigen test
Serology of IgA antibodies (not accurate with increasing patient age)
What are the causes of chemical gastritis?
What is the pathology of chemical gastritis?
Marked epithelial regeneration
Leads to Hyperplasia
- This may produce ulcers
What disease is related to gastritis?
Peptic ulcer disease
What is peptic ulceration?
A breach in the GI mucosa as a result of acid and pepsin attack
What are the most common place to get a peptic ulcer?
What are the complications of a peptic ulcer?
What are the benign gastric tumours?
Cystic fundic gland polyps
What are malignant gastric tumours?
GI stromal tumours
What increases the risk of gastric adenocarcinomas?
H Pylori infection
Patients with anti-h pylori antibodies have a higher risk of cancer
What is the pathology of gastric adenocarcimoma?
H pylori infection
What are the premalignant conditions to gastric cancer?
What is the feature of gastric cancer ?
Thickening of the stomach wall
Called Linitis plastica
How is gastric lymphoma intially treated?
Treated with antibiotics - to remove H pylori.
If Gastric lymphoma is let it will become a high grad B cell lymphoma
How is H pylori spread?
Oral-oral / faecal oral spred
What is the consequence of duodenal acid load?
H pylori colonisation
How does H pylori increase the pH of it microenvionment?
Urea + H2O + H+ --- Urease--> Ammonium Bicarbonate
H pylori reduces this process