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Flashcards in GDV Deck (17):
1

Israeli 2102;  Serum pepsinogen-A, canine pancreatic lipase immunoreactivity, and C-reactive protein as prognostic markers in dogs with gastric dilatation-volvulus JVIM 2012 Israeli 66 dogs with GDV 79 healthy controls Mortality rate in GDV dogs in this study was ____%

22.7 %

2

Pepsinogens are proenzymes secreted by ________ _______ ______. In humans, their serum concentrations reflect gastric mucosal morphological and functional status

gastric chief cells

3

Israeli 2012,          Pepsinogen-A, cPLI, and C-reactive protein were all commonly __________ in dogs with GDV. (increased or decreased)

increased

4

Israeli 2012 Pepsinogen-A was positively and significantly associated with .....?

severity of gastric wall lesion

5

Israeli 2012; Pepsinogen-A was increased in non-surviors (746 ug/L) compared with survivors (346 ug/L) of GDV in this study. As a predictor of outcome, what were the sensitivity and specificity? 

sensitivity and specificity of 53% and 88%, respectively (only a moderte predictor of outcome)

6

Israeli 2012; C Reactive Protein was increased in __% of dogs.

75%

7

Israeli 2012; cPLI was >200 μg/L in ___% of dogs and >400 μg/L in ____%

cPLI was >200 μg/L  in 39.4% and >400 μg/L in 18.2%

 

8

Serum pepsinogen-A, canine pancreatic lipase immunoreactivity, and C-reactive protein as prognostic markers in dogs with gastric dilatation-volvulus JVIM 2012 Israeli
Which of the biomarkers in this study were significantly associated with outcome?

none

9

Green 11 Evaluation of initial plasma lactate values as a predictor of gastric necrosis and initial and subsequent plasma lactate values as a predictor of survival in dogs with gastric dilatation-volvulus: 84 dogs (2003-2007). JVECC 2011 Green; Results: Was there a significant relationship found between survival and presence of gastric wall necrosis w/ initial plasma lactate ≥ 6 mmol/L???  

No, No, No, No, There was no significant relationship found between survival and presence of gastric wall necrosis w/ initial plasma lactate ≥ 6 mmol/L.   

10

Green 11; Evaluation of initial plasma lactate values as a predictor of gastric necrosis and initial and subsequent plasma lactate values as a predictor of survival in dogs with gastric dilatation-volvulus: 84 dogs (2003-2007). JVECC 2011 Green; There was a significant relationship between the initial plasma lactate >___ mmol/L for predicting necrosis and <___ mmol for predicting survival to discharge.>  

There was a significant relationship between the initial plasma lactate >2.9 mmol/L for predicting necrosis and <4.1 mmol/L for predicting survival to discharge.

11

Green GDV paper: The 3/40 that died failed to decrease their plasma lactate by ≥ __% from the initial blood lactate.

The 3/40 that died failed to decrease their plasma lactate by ≥ 50% from the initial blood lactate.

12

Green GDV paper; Forty dogs that had an increased initial plasma lactate (>2.5 mmol/L) also had a subsequent plasma lactate measured within 12 hours of presentation, with 37/40 dogs surviving and __% of these surviving dogs having the subsequent lactate decrease by ≥ __% within 12 hours.

Forty dogs that had an increased initial plasma lactate (>2.5 mmol/L) also had a subsequent plasma lactate measured within 12 hours of presentation, with 37/40 dogs surviving and 70% of these surviving dogs having the subsequent lactate decrease by ≥ 50% within 12 hours.

13

Zacher 10 Association between outcome and changes in plasma lactate concentration during presurgical treatment in dogs with gastric dilatation-volvulus: 64 cases (2002-2008).  JAVMA 2010  

36 of 40 (90%) dogs with an initial lactate concentration 9.0 mmol/L). 

 

14

Zacher 2010 GDV paper

36 of 40 (90%) dogs with an initial lactate concentration 9.0 mmol/L). Within HIL dogs, there was no difference in mean +/- SD initial lactate concentration between survivors and nonsurvivors (10.6 +/- 2.3 mmol/L vs 11.2 +/- 2.3 mmol/L, respectively); however, there were significant differences in post-treatment lactate concentration, absolute change in lactate concentration, and percentage change in lactate concentration following resuscitative treatment. By use of optimal cutoff values within HIL dogs, survival rates for dogs with final lactate concentration > 6.4 mmol/L (23%), absolute change in lactate concentration 4 mmol/L (86%), or percentage change in lactate concentration > 42.5% (100%).
 

15

Zacher 2010 GDV paper
 

36 of 40 (90%) dogs with an initial lactate concentration 9.0 mmol/L). Within HIL dogs, there was no difference in mean +/- SD initial lactate concentration between survivors and nonsurvivors (10.6 +/- 2.3 mmol/L vs 11.2 +/- 2.3 mmol/L, respectively); however, there were significant differences in post-treatment lactate concentration, absolute change in lactate concentration, and percentage change in lactate concentration following resuscitative treatment. By use of optimal cutoff values within HIL dogs, survival rates for dogs with final lactate concentration > 6.4 mmol/L (23%), absolute change in lactate concentration 4 mmol/L (86%), or percentage change in lactate concentration > 42.5% (100%).
 

16

Zacher 2010 GDV paper   Within HIL (high initial lactate) dogs, there was no difference in mean initial lactate concentration between survivors and nonsurvivors; however, there were significant differences in what 3 things (in regards to lactate) following ressussitation?
 

 there were significant differences in post-treatment lactate concentration, absolute change in lactate concentration, and percentage change in lactate concentration following resuscitative treatment.

17

Zacher 2010 GDV paper      Survival rates for dogs with final lactate concentration > ___ mmol/L, absolute change in lactate concentration  __ mmol/L, or percentage change in lactate concentration > ____ (100%).

 

Survival rates for dogs with final lactate concentration > 6.4 mmol/L (23%), absolute change in lactate concentration 4 mmol/L (86%), or percentage change in lactate concentration > 42.5% (100%).