Gene, Familial syndrome, Sporadic cancer Flashcards Preview

Zak, MOD 2 > Gene, Familial syndrome, Sporadic cancer > Flashcards

Flashcards in Gene, Familial syndrome, Sporadic cancer Deck (10):
1

APC

Familial = colonic polyps/carcinomas
Sporadic = stomach, colon, pancreatic carcinomas

2

NF1

Familial = Neurofibromatosis 1
Sporadic = neuroblastoma, juvenile myeloid leukemia

3

NF2

Familial = Neurofibromatosis 2
Sporadic = Schwannoma, meningioma

4

PTCH

Familial = Gorlin syndrome
Sporadic = Basal cell carcinoma, medulloblastoma

5

RB

Familial = RB
Sporadic = RB, osteosarcoma; breast, colon, lung carcinomas

6

VHL

Familial = VHL syndrome
Sporadic = Renal cell carcinoma

7

CDH1

Familial = gastric cancer
Sporadic = gastric carcinoma, lobular breast carcinoma

8

BRCA1/2

Familial = breast/ovarian carcinoma
Familial BRCA2 --> CLL

9

MSH

Familial = nonpolyposis colon carcinoma
Sporadic = colonic, endometrial carcinomas

10

WT1

Familial = Wilms tumor
Sporadic = Wilms tumor, leukemias