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Flashcards in general anesthetics Deck (17):
1

desflurane

-inhaled anesthetic
-volatile (liquid at room temp)
-lowest solubility (lowest blood:gas partition coefficient)
-increase heart rate

2

enflurane

-inhaled anesthetic
-volatile (liquid at room temp)
-can cause renal toxicity from fluoride ions

3

halothane

-inhaled anesthetic
-volatile (liquid at room temp)
-highest solubility (highest blood:gas partition coefficient)
-bradycardia
-can cause hepatitis 2 days - 3 weeks after

4

isoflurane

-inhaled anesthetic
-volatile (liquid at room temp)
-increase heart rate

5

nitrous oxide

-inhaled anesthetic
-gaseous
-low solubility (low blood:gas partition coefficient)

6

sevoflurane

-inhaled anesthetic
-volatile (liquid at room temp)
-can cause renal toxicity from fluoride ions

7

dexmedetomidine

-intravenous anesthetic
-A2 agonist
-causes hypnosis and analgesic effect
-decrease in HR and BP
-principally for short term sedation of intubated/ventilated ICU pt

8

diazepam

-intravenous anesthetic-benzodiazepines
-increases GABAa sensitivity to open more FREQUENTLY
-reversible with flumazenil

9

etomidate

-intravenous anesthetic
-rapid onset / moderate recovery
-decreased steroidogenesis, inhibits 11b-hdroxylase
-enhances action of GABA on GABAa receptor
-minimal CV and respiratory depression
-decreases cerebral blood flow

10

fentanyl

-intravenous anesthetic
-slow onset/recovery
-reversible with naloxone
-produces marked analgesia
-opioid analgesic
-agonist to opiate receptor

11

fospropofol

-intravenous anesthetic
-propofol pro-drug
-slower onset/recovery
-can cause paresthesias and pruritus

12

ketamine

-intravenous anesthetic
-moderate onset/recovery
-increased cerebral blood flow and cerebral metabolic rate for oxygen
-NMDA antagonist
-no loss of consciousness
-increase lacrimation and salivation
-can cause vivid color dreams, hallucinations, out-of-body experience, euphoric state
-increase in BP, HR, CO; but a myocardial depressant without sympathetic activity

13

lorazepam

-intravenous anesthetic
-benzodiazepines
-increases GABAa sensitivity to open more FREQUENTLY
-reversible with flumazenil

14

methohexital

-intravenous anesthetic
-barbiturate
-more rapid recovery than thiopental
-respiratory depression
-increases DURATION of GABAa opening

15

midazolam

-intravenous anesthetic
-slow onset/recovery
-reversible with flumazenil
-benzodiazepine
-increases GABAa sensitivity to open more FREQUENTLY
-water soluble
-patent anticonvulsant properties
-anterograde amnesia

16

propofol

-intravenous anesthetic
-GABAa agonist
-rapid onset/recovery
-hypotension - vasodilation
-useful antiemetic action
-decreases cerebral blood flow and cerebral metabolic rate for oxygen
-respiratory depressant
-pain on injection

17

thiopental

-intravenous anesthetic
-rapid onset/recovery in bolus not infusion
-CV depression
-barbiturate
-respiratory depression
-increases DURATION of GABAa opening