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Flashcards in General Principles - Blue book Deck (51)
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1

What is the body's innate response to injury?

inflammation

2

What are the 5 cardinal signs of inflammation?

rubor
Dolor
calor
tumor
Functio laesa

3

What is rubor? What causes it?

Redness
Due to vasodilator caused by histamine

4

What is dolor?

Pain
Due to kallikrein and bradykinin

5

What is calor?

heat
Due to increased vascularity due to histamine and serotonin

6

What is tumor?

Swelling due to increased vascular permeability - histamine and serotonin

7

What is functio laesa

Loss of function
Due to decreased cell functioning

8

What are the cellular responses to tissue injury or inflammation?

margination
Chemotaxis
Rolling and adhesion
pavementation
Emigration
phagocytosis

9

This is the way WBCs move to the periphery of the blood vessel by chemotaxis.

margination

10

This is due to inflammatory compounds which attract WBCs.

chemotaxis

11

Refers to WBCs sticking to the endothelium

pavementation

12

The passage of WBCs through blood vessels facilitated by chemotaxis.

emigration

13

What two types of things happen in emigration?

diapedsis or transmigration

14

Which cells phagocytize in in injured tissues?

macrophages

15

What are the Hemodynamics (vascular) changes?

Initial vasoconstriction
vasodilation
Increased vascular permeability
Blood stasis

16

How long does the initial vasodilation happen?

A few seconds

17

Vasodilator is mediated by what?

Histamine
bradykinin and kallikrien
Serotonin
prostaglandins

18

Histamine is released by the degranulation of which cells?

Basophils (and related mast cells)

19

bradykinin and kallkrein are responsible for what?

nociception

20

Serotonin is released by what?

platelets

21

Which compounds are responsible for further inflammation?

prostaglandins

22

Blood stasis is due to what?

Increased viscosity

23

What is a pus filled cavity called?

abcess

24

These result in there is a loss of surface epithelium.

ulcer

25

This is an abnormal communication between two epithelial surfaces.

Fistula (vesicolic fistula)

26

A blind ended tract connected to one epithelial surface.

sinus

27

Occurs when tissue healing and is characterized by fibrous tissue.

scar

28

A tumorous overgrowth of fibrous tissue in a scar. MC in black people.

keloid

29

What cells are found in chronic inflammation?

epithelioid cells, Langhans giant cells, and granulomas

30

These cells seen in chronic inflammation are activated macrophages found in granulomatous conditions like TB.

epithelioid cells